Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)
1_MQPRW 6_ AQGAT 11_ MWLGV 16_ LLTLL 21_ LCSSL 26_ EGQEN 31_ SFTIN 36_ SVDMK 41_ SLPDW 46_ TVQNG 51_ KNLTL 56_ QCFAD 61_ VSTTS 66_ HVKPQ 71_ HQMLF 76_ YKDDV 81_ LFYNI 86_ SSMKS 91_ TESYF 96_ IPEVR 101_ IYDSG 106_ TYKCT 111_ VIVNN 116_ KEKTT 121_ AEYQV 126_ LVEGV 131_ PSPRV 136_ TLDKK 141_ EAIQG 146_ GIVRV 151_ NCSVP 156_ EEKAP 161_ IHFTI 166_ EKLEL 171_ NEKMV 176_ KLKRE 181_ KNSRD 186_ QNFVI 191_ LEFPV 196_ EEQDR 201_ VLSFR 206_ CQARI 211_ ISGIH 216_ MQTSE 221_ STKSE 226_ LVTVT 231_ ESFST 236_ PKFHI 241_ SPTGM 246_ IMEGA 251_ QLHIK 256_ CTIQV 261_ THLAQ 266_ EFPEI 271_ IIQKD 276_ KAIVA 281_ HNRHG 286_ NKAVY 291_ SVMAM 296_ VEHSG 301_ NYTCK 306_ VESSR 311_ ISKVS 316_ SIVVN 321_ ITELF 326_ SKPEL 331_ ESSFT 336_ HLDQG 341_ ERLNL 346_ SCSIP 351_ GAPPA 356_ NFTIQ 361_ KEDTI 366_ VSQTQ 371_ DFTKI 376_ ASKSD 381_ SGTYI 386_ CTAGI 391_ DKVVK 396_ KSNTV 401_ QIVVC 406_ EMLSQ 411_ PRISY 416_ DAQFE 421_ VIKGQ 426_ TIEVR 431_ CESIS 436_ GTLPI 441_ SYQLL 446_ KTSKV 451_ LENST 456_ KNSND 461_ PAVFK 466_ DNPTE 471_ DVEYQ 476_ CVADN 481_ CHSHA 486_ KMLSE 491_ VLRVK 496_ VIAPV 501_ DEVQI 506_ SILSS 511_ KVVES 516_ GEDIV 521_ LQCAV 526_ NEGSG 531_ PITYK 536_ FYREK 541_ EGKPF 546_ YQMTS 551_ NATQA 556_ FWTKQ 561_ KASKE 566_ QEGEY 571_ YCTAF 576_ NRANH 581_ ASSVP 586_ RSKIL 591_ TVRVI 596_ LAPWK 601_ KGLIA 606_ VVIIG 611_ VIIAL 616_ LIIAA 621_ KCYFL 626_ RKAKA 631_ KQMPV 636_ EMSRP 641_ AVPLL 646_ NSNNE 651_ KMSDP 656_ NMEAN 661_ SHYGH 666_ NDDVR 671_ NHAMK 676_ PINDN 681_ KEPLN 686_ SDVQY 691_ TEVQV 696_ SSAES 701_ HKDLG 706_ KKDTE 711_ TVYSE 716_ VRKAV 721_ PDAVE 726_ SRYSR 731_TEGSL
1: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity)
2: Does not protect against apoptosis