Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta)
1_MAAPE 6_ PARAA 11_ PPPPP 16_ PPPPP 21_ PGADR 26_ VVKAV 31_ PFPPT 36_ HRLTS 41_ EEVFD 46_ LDGIP 51_ RVDVL 56_ KNHLV 61_ KEGRV 66_ DEEIA 71_ LRIIN 76_ EGAAI 81_ LRREK 86_ TMIEV 91_ EAPIT 96_ VCGDI 101_ HGQFF 106_ DLMKL 111_ FEVGG 116_ SPANT 121_ RYLFL 126_ GDYVD 131_ RGYFS 136_ IECVL 141_ YLWVL 146_ KILYP 151_ STLFL 156_ LRGNH 161_ ECRHL 166_ TEYFT 171_ FKQEC 176_ KIKYS 181_ ERVYE 186_ ACMEA 191_ FDSLP 196_ LAALL 201_ NQQFL 206_ CVHGG 211_ LSPEI 216_ HTLDD 221_ IRRLD 226_ RFKEP 231_ PAFGP 236_ MCDLL 241_ WSDPS 246_ EDFGN 251_ EKSQE 256_ HFSHN 261_ TVRGC 266_ SYFYN 271_ YPAVC 276_ EFLQN 281_ NNLLS 286_ IIRAH 291_ EAQDA 296_ GYRMY 301_ RKSQT 306_ TGFPS 311_ LITIF 316_ SAPNY 321_ LDVYN 326_ NKAAV 331_ LKYEN 336_ NVMNI 341_ RQFNC 346_ SPHPY 351_ WLPNF 356_ MDVFT 361_ WSLPF 366_ VGEKV 371_ TEMLV 376_ NVLSI 381_ CSDDE 386_ LMTEG 391_ EDQFD 396_ GSAAA 401_ RKEII 406_ RNKIR 411_ AIGKM 416_ ARVFS 421_ VLREE 426_ SESVL 431_ TLKGL 436_ TPTGM 441_ LPSGV 446_ LAGGR 451_ QTLQS 456_ ATVEA 461_ IEAEK 466_ AIRGF 471_ SPPHR 476_ ICSFE 481_ EAKGL 486_ DRINE 491_ RMPPR 496_ KDAVQ 501_ QDGFN 506_ SLNTA 511_ HATEN 516_HGTGN
1: Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:25720963, PubMed:26794871, PubMed:32753672). Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (PubMed:25720963, PubMed:32753672). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity)