Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha)
1_MAEEV 6_ VVVAK 11_ FDYVA 16_ QQEQE 21_ LDIKK 26_ NERLW 31_ LLDDS 36_ KSWWR 41_ VRNSM 46_ NKTGF 51_ VPSNY 56_ VERKN 61_ SARKA 66_ SIVKN 71_ LKDTL 76_ GIGKV 81_ KRKPS 86_ VPDSA 91_ SPADD 96_ SFVDP 101_ GERLY 106_ DLNMP 111_ AYVKF 116_ NYMAE 121_ REDEL 126_ SLIKG 131_ TKVIV 136_ MEKCS 141_ DGWWR 146_ GSYNG 151_ QVGWF 156_ PSNYV 161_ TEEGD 166_ SPLGD 171_ HVGSL 176_ SEKLA 181_ AVVNN 186_ LNTGQ 191_ VLHVV 196_ QALYP 201_ FSSSN 206_ DEELN 211_ FEKGD 216_ VMDVI 221_ EKPEN 226_ DPEWW 231_ KCRKI 236_ NGMVG 241_ LVPKN 246_ YVTVM 251_ QNNPL 256_ TSGLE 261_ PSPPQ 266_ CDYIR 271_ PSLTG 276_ KFAGN 281_ PWYYG 286_ KVTRH 291_ QAEMA 296_ LNERG 301_ HEGDF 306_ LIRDS 311_ ESSPN 316_ DFSVS 321_ LKAQG 326_ KNKHF 331_ KVQLK 336_ ETVYC 341_ IGQRK 346_ FSTME 351_ ELVEH 356_ YKKAP 361_ IFTSE 366_ QGEKL 371_YLVKH
1: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors