Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD antigen CD152)
1_MACLG 6_ FQRHK 11_ AQLNL 16_ ATRTW 21_ PCTLL 26_ FFLLF 31_ IPVFC 36_ KAMHV 41_ AQPAV 46_ VLASS 51_ RGIAS 56_ FVCEY 61_ ASPGK 66_ ATEVR 71_ VTVLR 76_ QADSQ 81_ VTEVC 86_ AATYM 91_ MGNEL 96_ TFLDD 101_ SICTG 106_ TSSGN 111_ QVNLT 116_ IQGLR 121_ AMDTG 126_ LYICK 131_ VELMY 136_ PPPYY 141_ LGIGN 146_ GTQIY 151_ VIDPE 156_ PCPDS 161_ DFLLW 166_ ILAAV 171_ SSGLF 176_ FYSFL 181_ LTAVS 186_ LSKML 191_ KKRSP 196_ LTTGV 201_ YVKMP 206_ PTEPE 211_ CEKQF 216_QPYFI
1: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28