Dipeptidase 1 (EC 3.4.13.19) (Beta-lactamase) (EC 3.5.2.6) (Dehydropeptidase-I) (Microsomal dipeptidase) (Renal dipeptidase) (hRDP)
1_MWSGW 6_ WLWPL 11_ VAVCT 16_ ADFFR 21_ DEAER 26_ IMRDS 31_ PVIDG 36_ HNDLP 41_ WQLLD 46_ MFNNR 51_ LQDER 56_ ANLTT 61_ LAGTH 66_ TNIPK 71_ LRAGF 76_ VGGQF 81_ WSVYT 86_ PCDTQ 91_ NKDAV 96_ RRTLE 101_ QMDVV 106_ HRMCR 111_ MYPET 116_ FLYVT 121_ SSAGI 126_ RQAFR 131_ EGKVA 136_ SLIGV 141_ EGGHS 146_ IDSSL 151_ GVLRA 156_ LYQLG 161_ MRYLT 166_ LTHSC 171_ NTPWA 176_ DNWLV 181_ DTGDS 186_ EPQSQ 191_ GLSPF 196_ GQRVV 201_ KELNR 206_ LGVLI 211_ DLAHV 216_ SVATM 221_ KATLQ 226_ LSRAP 231_ VIFSH 236_ SSAYS 241_ VCASR 246_ RNVPD 251_ DVLRL 256_ VKQTD 261_ SLVMV 266_ NFYNN 271_ YISCT 276_ NKANL 281_ SQVAD 286_ HLDHI 291_ KEVAG 296_ ARAVG 301_ FGGDF 306_ DGVPR 311_ VPEGL 316_ EDVSK 321_ YPDLI 326_ AELLR 331_ RNWTE 336_ AEVKG 341_ ALADN 346_ LLRVF 351_ EAVEQ 356_ ASNLT 361_ QAPEE 366_ EPIPL 371_ DQLGG 376_ SCRTH 381_ YGYSS 386_ GASSL 391_ HRHWG 396_ LLLAS 401_ LAPLV 406_LCLSL
1: Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490, PubMed:31442408, PubMed:32325220, PubMed:6334084). Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (PubMed:32325220). Also possesses beta lactamase activity and can hydrolyze the beta-lactam antibiotic imipenem (PubMed:32325220, PubMed:6334084)
2: Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver