Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase)
1_MDKDC 6_ EMKRT 11_ TLDSP 16_ LGKLE 21_ LSGCE 26_ QGLHE 31_ IKLLG 36_ KGTSA 41_ ADAVE 46_ VPAPA 51_ AVLGG 56_ PEPLM 61_ QCTAW 66_ LNAYF 71_ HQPEA 76_ IEEFP 81_ VPALH 86_ HPVFQ 91_ QESFT 96_ RQVLW 101_ KLLKV 106_ VKFGE 111_ VISYQ 116_ QLAAL 121_ AGNPK 126_ AARAV 131_ GGAMR 136_ GNPVP 141_ ILIPC 146_ HRVVC 151_ SSGAV 156_ GNYSG 161_ GLAVK 166_ EWLLA 171_ HEGHR 176_ LGKPG 181_ LGGSS 186_ GLAGA 191_ WLKGA 196_ GATSG 201_SPPAG
1: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated