Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer)
1_MGFGS 6_ DLKNS 11_ HEAVL 16_ KLQDW 21_ ELRLL 26_ ETVKK 31_ FMALR 36_ IKSDK 41_ EYAST 46_ LQNLC 51_ NQVDK 56_ ESTVQ 61_ MNYVS 66_ NVSKS 71_ WLLMI 76_ QQTEQ 81_ LSRIM 86_ KTHAE 91_ DLNSG 96_ PLHRL 101_ TMMIK 106_ DKQQV 111_ KKSYI 116_ GVHQQ 121_ IEAEM 126_ IKVTK 131_ TELEK 136_ LKCSY 141_ RQLIK 146_ EMNSA 151_ KEKYK 156_ EALAK 161_ GKETE 166_ KAKER 171_ YDKAT 176_ MKLHM 181_ LHNQY 186_ VLALK 191_ GAQLH 196_ QNQYY 201_ DITLP 206_ LLLDS 211_ LQKMQ 216_ EEMIK 221_ ALKGI 226_ FDEYS 231_ QITSL 236_ VTEEI 241_ VNVHK 246_ EIQMS 251_ VEQID 256_ PSTEY 261_ NNFID 266_ VHRTT 271_ AAKEQ 276_ EIEFD 281_ TSLLE 286_ ENENL 291_ QANEI 296_ MWNNL 301_ TAESL 306_ QVMLK 311_ TLAEE 316_ LMQTQ 321_ QMLLN 326_ KEEAV 331_ LELEK 336_ RIEES 341_ SETCE 346_ KKSDI 351_ VLLLS 356_ QKQAL 361_ EELKQ 366_ SVQQL 371_ RCTEA 376_ KFSAQ 381_ KELLE 386_ QKVQE 391_ NDGKE 396_ PPPVV 401_ NYEED 406_ ARSVT 411_ SMERK 416_ ERLSK 421_ FESIR 426_ HSIAG 431_ IIRSP 436_ KSALG 441_ SSALS 446_ DMISI 451_ SEKPL 456_ AEQDW 461_ YHGAI 466_ PRIEA 471_ QELLK 476_ KQGDF 481_ LVRES 486_ HGKPG 491_ EYVLS 496_ VYSDG 501_ QRRHF 506_ IIQYV 511_ DNMYR 516_ FEGTG 521_ FSNIP 526_ QLIDH 531_ HYTTK 536_ QVITK 541_ KSGVV 546_ LLNPI 551_ PKDKK 556_ WILSH 561_ EDVIL 566_ GELLG 571_ KGNFG 576_ EVYKG 581_ TLKDK 586_ TSVAV 591_ KTCKE 596_ DLPQE 601_ LKIKF 606_ LQEAK 611_ ILKQY 616_ DHPNI 621_ VKLIG 626_ VCTQR 631_ QPVYI 636_ IMELV 641_ SGGDF 646_ LTFLR 651_ RKKDE 656_ LKLKQ 661_ LVKFS 666_ LDAAA 671_ GMLYL 676_ ESKNC 681_ IHRDL 686_ AARNC 691_ LVGEN 696_ NVLKI 701_ SDFGM 706_ SRQED 711_ GGVYS 716_ SSGLK 721_ QIPIK 726_ WTAPE 731_ ALNYG 736_ RYSSE 741_ SDVWS 746_ FGILL 751_ WETFS 756_ LGVCP 761_ YPGMT 766_ NQQAR 771_ EQVER 776_ GYRMS 781_ APQHC 786_ PEDIS 791_ KIMMK 796_ CWDYK 801_ PENRP 806_ KFSEL 811_ QKELT 816_IIKRK
1: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus