Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
1_MENAH 6_ TKTVE 11_ EVLGH 16_ FGVNE 21_ STGLS 26_ LEQVK 31_ KLKER 36_ WGSNE 41_ LPAEE 46_ GKTLL 51_ ELVIE 56_ QFEDL 61_ LVRIL 66_ LLAAC 71_ ISFVL 76_ AWFEE 81_ GEETI 86_ TAFVE 91_ PFVIL 96_ LILVA 101_ NAIVG 106_ VWQER 111_ NAENA 116_ IEALK 121_ EYEPE 126_ MGKVY 131_ RQDRK 136_ SVQRI 141_ KAKDI 146_ VPGDI 151_ VEIAV 156_ GDKVP 161_ ADIRL 166_ TSIKS 171_ TTLRV 176_ DQSIL 181_ TGESV 186_ SVIKH 191_ TDPVP 196_ DPRAV 201_ NQDKK 206_ NMLFS 211_ GTNIA 216_ AGKAM 221_ GVVVA 226_ TGVNT 231_ EIGKI 236_ RDEMV 241_ ATEQE 246_ RTPLQ 251_ QKLDE 256_ FGEQL 261_ SKVIS 266_ LICIA 271_ VWIIN 276_ IGHFN 281_ DPVHG 286_ GSWIR 291_ GAIYY 296_ FKIAV 301_ ALAVA 306_ AIPEG 311_ LPAVI 316_ TTCLA 321_ LGTRR 326_ MAKKN 331_ AIVRS 336_ LPSVE 341_ TLGCT 346_ SVICS 351_ DKTGT 356_ LTTNQ 361_ MSVCR 366_ MFILD 371_ RVEGD 376_ TCSLN 381_ EFTIT 386_ GSTYA 391_ PIGEV 396_ HKDDK 401_ PVNCH 406_ QYDGL 411_ VELAT 416_ ICALC 421_ NDSAL 426_ DYNEA 431_ KGVYE 436_ KVGEA 441_ TETAL 446_ TCLVE 451_ KMNVF 456_ DTELK 461_ GLSKI 466_ ERANA 471_ CNSVI 476_ KQLMK 481_ KEFTL 486_ EFSRD 491_ RKSMS 496_ VYCTP 501_ NKPSR 506_ TSMSK 511_ MFVKG 516_ APEGV 521_ IDRCT 526_ HIRVG 531_ STKVP 536_ MTSGV 541_ KQKIM 546_ SVIRE 551_ WGSGS 556_ DTLRC 561_ LALAT 566_ HDNPL 571_ RREEM 576_ HLEDS 581_ ANFIK 586_ YETNL 591_ TFVGC 596_ VGMLD 601_ PPRIE 606_ VASSV 611_ KLCRQ 616_ AGIRV 621_ IMITG 626_ DNKGT 631_ AVAIC 636_ RRIGI 641_ FGQDE 646_ DVTSK 651_ AFTGR 656_ EFDEL 661_ NPSAQ 666_ RDACL 671_ NARCF 676_ ARVEP 681_ SHKSK 686_ IVEFL 691_ QSFDE 696_ ITAMT 701_ GDGVN 706_ DAPAL 711_ KKAEI 716_ GIAMG 721_ SGTAV 726_ AKTAS 731_ EMVLA 736_ DDNFS 741_ TIVAA 746_ VEEGR 751_ AIYNN 756_ MKQFI 761_ RYLIS 766_ SNVGE 771_ VVCIF 776_ LTAAL 781_ GFPEA 786_ LIPVQ 791_ LLWVN 796_ LVTDG 801_ LPATA 806_ LGFNP 811_ PDLDI 816_ MNKPP 821_ RNPKE 826_ PLISG 831_ WLFFR 836_ YLAIG 841_ CYVGA 846_ ATVGA 851_ AAWWF 856_ IAADG 861_ GPRVS 866_ FYQLS 871_ HFLQC 876_ KEDNP 881_ DFEGV 886_ DCAIF 891_ ESPYP 896_ MTMAL 901_ SVLVT 906_ IEMCN 911_ ALNSL 916_ SENQS 921_ LLRMP 926_ PWENI 931_ WLVGS 936_ ICLSM 941_ SLHFL 946_ ILYVE 951_ PLPLI 956_ FQITP 961_ LNVTQ 966_ WLMVL 971_ KISLP 976_ VILMD 981_ ETLKF 986_ VARNY 991_ LEPGK 996_ ECVQP 1001_ ATKSC 1006_ SFSAC 1011_ TDGIS 1016_ WPFVL 1021_ LIMPL 1026_ VIWVY 1031_ STDTN 1036_FSDMF
1: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity)
2: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation