UDP-glucuronosyltransferase 2B7 (UDPGT 2B7) (UGT2B7) (EC 2.4.1.17) (3,4-catechol estrogen-specific UDPGT) (UDP-glucuronosyltransferase 2B9) (UDPGT 2B9) (UDPGTh-2)
1_MSVKW 6_ TSVIL 11_ LIQLS 16_ FCFSS 21_ GNCGK 26_ VLVWA 31_ AEYSH 36_ WMNIK 41_ TILDE 46_ LIQRG 51_ HEVTV 56_ LASSA 61_ SILFD 66_ PNNSS 71_ ALKIE 76_ IYPTS 81_ LTKTE 86_ LENFI 91_ MQQIK 96_ RWSDL 101_ PKDTF 106_ WLYFS 111_ QVQEI 116_ MSIFG 121_ DITRK 126_ FCKDV 131_ VSNKK 136_ FMKKV 141_ QESRF 146_ DVIFA 151_ DAIFP 156_ CSELL 161_ AELFN 166_ IPFVY 171_ SLSFS 176_ PGYTF 181_ EKHSG 186_ GFIFP 191_ PSYVP 196_ VVMSE 201_ LTDQM 206_ TFMER 211_ VKNMI 216_ YVLYF 221_ DFWFE 226_ IFDMK 231_ KWDQF 236_ YSEVL 241_ GRPTT 246_ LSETM 251_ GKADV 256_ WLIRN 261_ SWNFQ 266_ FPYPL 271_ LPNVD 276_ FVGGL 281_ HCKPA 286_ KPLPK 291_ EMEDF 296_ VQSSG 301_ ENGVV 306_ VFSLG 311_ SMVSN 316_ MTEER 321_ ANVIA 326_ SALAQ 331_ IPQKV 336_ LWRFD 341_ GNKPD 346_ TLGLN 351_ TRLYK 356_ WIPQN 361_ DLLGH 366_ PKTRA 371_ FITHG 376_ GANGI 381_ YEAIY 386_ HGIPM 391_ VGIPL 396_ FADQP 401_ DNIAH 406_ MKARG 411_ AAVRV 416_ DFNTM 421_ SSTDL 426_ LNALK 431_ RVIND 436_ PSYKE 441_ NVMKL 446_ SRIQH 451_ DQPVK 456_ PLDRA 461_ VFWIE 466_ FVMRH 471_ KGAKH 476_ LRVAA 481_ HDLTW 486_ FQYHS 491_ LDVIG 496_ FLLVC 501_ VATVI 506_ FIVTK 511_ CCLFC 516_ FWKFA 521_RKAKK
1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:10702251, PubMed:15470161, PubMed:15472229, PubMed:17442341, PubMed:18674515, PubMed:18719240, PubMed:19022937, PubMed:23288867, PubMed:23756265, PubMed:26220143, PubMed:15231852, PubMed:21422672, PubMed:38211441). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15470161, PubMed:18674515, PubMed:23756265). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:15472229, PubMed:17442341, PubMed:18719240, PubMed:19022937, PubMed:2159463, PubMed:23288867, PubMed:26220143). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development (PubMed:10702251). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE, PGE2, PGB1 and F2-isoprostanes (8-iso-PGF2alpha and 5-epi-5-F2t-IsoP) (PubMed:15231852, PubMed:38211441). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (PubMed:21422672). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161)