Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A)
1_MAPPS 6_ VFAEV 11_ PQAQP 16_ VLVFK 21_ LTADF 26_ REDPD 31_ PRKVN 36_ LGVGA 41_ YRTDD 46_ CHPWV 51_ LPVVK 56_ KVEQK 61_ IANDN 66_ SLNHE 71_ YLPIL 76_ GLAEF 81_ RSCAS 86_ RLALG 91_ DDSPA 96_ LKEKR 101_ VGGVQ 106_ SLGGT 111_ GALRI 116_ GADFL 121_ ARWYN 126_ GTNNK 131_ NTPVY 136_ VSSPT 141_ WENHN 146_ AVFSA 151_ AGFKD 156_ IRSYR 161_ YWDAE 166_ KRGLD 171_ LQGFL 176_ NDLEN 181_ APEFS 186_ IVVLH 191_ ACAHN 196_ PTGID 201_ PTPEQ 206_ WKQIA 211_ SVMKH 216_ RFLFP 221_ FFDSA 226_ YQGFA 231_ SGNLE 236_ RDAWA 241_ IRYFV 246_ SEGFE 251_ FFCAQ 256_ SFSKN 261_ FGLYN 266_ ERVGN 271_ LTVVG 276_ KEPES 281_ ILQVL 286_ SQMEK 291_ IVRIT 296_ WSNPP 301_ AQGAR 306_ IVAST 311_ LSNPE 316_ LFEEW 321_ TGNVK 326_ TMADR 331_ ILTMR 336_ SELRA 341_ RLEAL 346_ KTPGT 351_ WNHIT 356_ DQIGM 361_ FSFTG 366_ LNPKQ 371_ VEYLV 376_ NEKHI 381_ YLLPS 386_ GRINV 391_ SGLTT 396_ KNLDY 401_ VATSI 406_HEAVT
1: Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456)