Bactericidal permeability-increasing protein (BPI) (CAP 57)
1_MRENM 6_ ARGPC 11_ NAPRW 16_ ASLMV 21_ LVAIG 26_ TAVTA 31_ AVNPG 36_ VVVRI 41_ SQKGL 46_ DYASQ 51_ QGTAA 56_ LQKEL 61_ KRIKI 66_ PDYSD 71_ SFKIK 76_ HLGKG 81_ HYSFY 86_ SMDIR 91_ EFQLP 96_ SSQIS 101_ MVPNV 106_ GLKFS 111_ ISNAN 116_ IKISG 121_ KWKAQ 126_ KRFLK 131_ MSGNF 136_ DLSIE 141_ GMSIS 146_ ADLKL 151_ GSNPT 156_ SGKPT 161_ ITCSS 166_ CSSHI 171_ NSVHV 176_ HISKS 181_ KVGWL 186_ IQLFH 191_ KKIES 196_ ALRNK 201_ MNSQV 206_ CEKVT 211_ NSVSS 216_ ELQPY 221_ FQTLP 226_ VMTKI 231_ DSVAG 236_ INYGL 241_ VAPPA 246_ TTAET 251_ LDVQM 256_ KGEFY 261_ SENHH 266_ NPPPF 271_ APPVM 276_ EFPAA 281_ HDRMV 286_ YLGLS 291_ DYFFN 296_ TAGLV 301_ YQEAG 306_ VLKMT 311_ LRDDM 316_ IPKES 321_ KFRLT 326_ TKFFG 331_ TFLPE 336_ VAKKF 341_ PNMKI 346_ QIHVS 351_ ASTPP 356_ HLSVQ 361_ PTGLT 366_ FYPAV 371_ DVQAF 376_ AVLPN 381_ SSLAS 386_ LFLIG 391_ MHTTG 396_ SMEVS 401_ AESNR 406_ LVGEL 411_ KLDRL 416_ LLELK 421_ HSNIG 426_ PFPVE 431_ LLQDI 436_ MNYIV 441_ PILVL 446_ PRVNE 451_ KLQKG 456_ FPLPT 461_ PARVQ 466_ LYNVV 471_ LQPHQ 476_ NFLLF 481_GADVV
1: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa