Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)
1_MGDWS 6_ ALGKL 11_ LDKVQ 16_ AYSTA 21_ GGKVW 26_ LSVLF 31_ IFRIL 36_ LLGTA 41_ VESAW 46_ GDEQS 51_ AFRCN 56_ TQQPG 61_ CENVC 66_ YDKSF 71_ PISHV 76_ RFWVL 81_ QIIFV 86_ SVPTL 91_ LYLAH 96_ VFYVM 101_ RKEEK 106_ LNKKE 111_ EELKV 116_ AQTDG 121_ VNVDM 126_ HLKQI 131_ EIKKF 136_ KYGIE 141_ EHGKV 146_ KMRGG 151_ LLRTY 156_ IISIL 161_ FKSIF 166_ EVAFL 171_ LIQWY 176_ IYGFS 181_ LSAVY 186_ TCKRD 191_ PCPHQ 196_ VDCFL 201_ SRPTE 206_ KTIFI 211_ IFMLV 216_ VSLVS 221_ LALNI 226_ IELFY 231_ VFFKG 236_ VKDRV 241_ KGKSD 246_ PYHAT 251_ SGALS 256_ PAKDC 261_ GSQKY 266_ AYFNG 271_ CSSPT 276_ APLSP 281_ MSPPG 286_ YKLVT 291_ GDRNN 296_ SSCRN 301_ YNKQA 306_ SEQNW 311_ ANYSA 316_ EQNRM 321_ GQAGS 326_ TISNS 331_ HAQPF 336_ DFPDD 341_ NQNSK 346_ KLAAG 351_ HELQP 356_ LAIVD 361_ QRPSS 366_ RASSR 371_ ASSRP 376_RPDDL
1: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity)