Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha-hydroxysteroid dehydrogenase type I) (3-alpha-HSD1) (EC 1.1.1.357) (3alpha-hydroxysteroid 3-dehydrogenase) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4) (HAKRA)
1_MDPKY 6_ QRVEL 11_ NDGHF 16_ MPVLG 21_ FGTYA 26_ PPEVP 31_ RNRAV 36_ EVTKL 41_ AIEAG 46_ FRHID 51_ SAYLY 56_ NNEEQ 61_ VGLAI 66_ RSKIA 71_ DGSVK 76_ REDIF 81_ YTSKL 86_ WCTFF 91_ QPQMV 96_ QPALE 101_ SSLKK 106_ LQLDY 111_ VDLYL 116_ LHFPM 121_ ALKPG 126_ ETPLP 131_ KDENG 136_ KVIFD 141_ TVDLS 146_ ATWEV 151_ MEKCK 156_ DAGLA 161_ KSIGV 166_ SNFNC 171_ RQLEM 176_ ILNKP 181_ GLKYK 186_ PVCNQ 191_ VECHP 196_ YLNQS 201_ KLLDF 206_ CKSKD 211_ IVLVA 216_ HSALG 221_ TQRHK 226_ LWVDP 231_ NSPVL 236_ LEDPV 241_ LCALA 246_ KKHKQ 251_ TPALI 256_ ALRYQ 261_ LQRGV 266_ VVLAK 271_ SYNEQ 276_ RIREN 281_ IQVFE 286_ FQLTS 291_ EDMKV 296_ LDGLN 301_ RNYRY 306_ VVMDF 311_ LMDHP 316_DYPFS
1: Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Liver specific enzyme that acts as an NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain (PubMed:10634139, PubMed:10998348, PubMed:11158055, PubMed:14672942, PubMed:1530633, PubMed:19218247, PubMed:7650035). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:14672942). Acts preferentially as a 3-alpha-hydroxysteroid dehydrogenase (HSD) with a subsidiary 3-beta-HSD activity (PubMed:14672942). Catalyzes efficiently the transformation of the potent androgen 5-alpha-dihydrotestosterone (5alpha-DHT or 17beta-hydroxy-5alpha-androstan-3-one) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10998348, PubMed:11158055, PubMed:14672942). Catalyzes the reduction of estrone into 17beta-estradiol but with low efficiency (PubMed:14672942). Metabolizes a broad spectrum of natural and synthetic therapeutic steroid and plays an important role in metabolism of androgens, estrogens, progestereone and conjugated steroids (PubMed:10998348, PubMed:14672942, PubMed:19218247). Catalyzes the biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leading to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route (PubMed:2427522)