Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A)
1_MGDDR 6_ PFVCN 11_ APGCG 16_ QRFTN 21_ EDHLA 26_ VHKHK 31_ HEMTL 36_ KFGPA 41_ RTDSV 46_ IIADQ 51_ TPTPT 56_ RFLKN 61_ CEEVG 66_ LFNEL 71_ ASSFE 76_ HEFKK 81_ AADED 86_ EKKAA 91_ AGPLD 96_ MSLPS 101_ TPDIK 106_ IKEEE 111_ PVEVD 116_ SSPPD 121_ SPASS 126_ PCSPP 131_ LKEKE 136_ VTPKP 141_ VLIST 146_ PTPTI 151_ VRPGS 156_ LPLHL 161_ GYDPL 166_ HPTLP 171_ SPTSV 176_ ITQAP 181_ PSNRQ 186_ MGSPT 191_ GSLPL 196_ VMHLA 201_ NGQTM 206_ PVLPG 211_ PPVQM 216_ PSVIS 221_ LARPV 226_ SMVPN 231_ IPGIP 236_ GPPVN 241_ SSGSI 246_ SPSGH 251_ PIPSE 256_ AKMRL 261_ KATLT 266_ HQVSS 271_ INGGC 276_ GMVVG 281_ TASTM 286_ VTARP 291_ EQSQI 296_ LIQHP 301_ DAPSP 306_ AQPQV 311_ SPAQP 316_ TPSTG 321_ GRRRR 326_ TVDED 331_ PDERR 336_ QRFLE 341_ RNRAA 346_ ASRCR 351_ QKRKL 356_ WVSSL 361_ EKKAE 366_ ELTSQ 371_ NIQLS 376_ NEVTL 381_ LRNEV 386_ AQLKQ 391_ LLLAH 396_ KDCPV 401_ TALQK 406_ KTQGY 411_ LESPK 416_ ESSEP 421_ TGSPA 426_ PVIQH 431_ SSATA 436_ PSNGL 441_ SVRSA 446_ AEAVA 451_ TSVLT 456_ QMASQ 461_ RTELS 466_ MPIQS 471_ HVIMT 476_PQSQS
1: Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation (PubMed:29490055). In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes (By similarity). Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (By similarity). In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening (PubMed:29490055). Also plays a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (By similarity)
2: Acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter
3: Acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation