5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA oxidase) (EC 1.14.18.-) (Catalase B) (Glycoprotein 75) (Melanoma antigen gp75) (Tyrosinase-related protein 1) (TRP) (TRP-1) (TRP1)
1_MSAPK 6_ LLSLG 11_ CIFFP 16_ LLLFQ 21_ QARAQ 26_ FPRQC 31_ ATVEA 36_ LRSGM 41_ CCPDL 46_ SPVSG 51_ PGTDR 56_ CGSSS 61_ GRGRC 66_ EAVTA 71_ DSRPH 76_ SPQYP 81_ HDGRD 86_ DREVW 91_ PLRFF 96_ NRTCH 101_ CNGNF 106_ SGHNC 111_ GTCRP 116_ GWRGA 121_ ACDQR 126_ VLIVR 131_ RNLLD 136_ LSKEE 141_ KNHFV 146_ RALDM 151_ AKRTT 156_ HPLFV 161_ IATRR 166_ SEEIL 171_ GPDGN 176_ TPQFE 181_ NISIY 186_ NYFVW 191_ THYYS 196_ VKKTF 201_ LGVGQ 206_ ESFGE 211_ VDFSH 216_ EGPAF 221_ LTWHR 226_ YHLLR 231_ LEKDM 236_ QEMLQ 241_ EPSFS 246_ LPYWN 251_ FATGK 256_ NVCDI 261_ CTDDL 266_ MGSRS 271_ NFDST 276_ LISPN 281_ SVFSQ 286_ WRVVC 291_ DSLED 296_ YDTLG 301_ TLCNS 306_ TEDGP 311_ IRRNP 316_ AGNVA 321_ RPMVQ 326_ RLPEP 331_ QDVAQ 336_ CLEVG 341_ LFDTP 346_ PFYSN 351_ STNSF 356_ RNTVE 361_ GYSDP 366_ TGKYD 371_ PAVRS 376_ LHNLA 381_ HLFLN 386_ GTGGQ 391_ THLSP 396_ NDPIF 401_ VLLHT 406_ FTDAV 411_ FDEWL 416_ RRYNA 421_ DISTF 426_ PLENA 431_ PIGHN 436_ RQYNM 441_ VPFWP 446_ PVTNT 451_ EMFVT 456_ APDNL 461_ GYTYE 466_ IQWPS 471_ REFSV 476_ PEIIA 481_ IAVVG 486_ ALLLV 491_ ALIFG 496_ TASYL 501_ IRARR 506_ SMDEA 511_ NQPLL 516_ TDQYQ 521_ CYAEE 526_ YEKLQ 531_NPNQS
1: Plays a role in melanin biosynthesis (PubMed:16704458, PubMed:22556244, PubMed:23504663). Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:16704458, PubMed:22556244). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity)