Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel HBK2) (Voltage-gated potassium channel subunit Kv1.6)
1_MRSEK 6_ SLTLA 11_ APGEV 16_ RGPEG 21_ EQQDA 26_ GDFPE 31_ AGGGG 36_ GCCSS 41_ ERLVI 46_ NISGL 51_ RFETQ 56_ LRTLS 61_ LFPDT 66_ LLGDP 71_ GRRVR 76_ FFDPL 81_ RNEYF 86_ FDRNR 91_ PSFDA 96_ ILYYY 101_ QSGGR 106_ LRRPV 111_ NVPLD 116_ IFLEE 121_ IRFYQ 126_ LGDEA 131_ LAAFR 136_ EDEGC 141_ LPEGG 146_ EDEKP 151_ LPSQP 156_ FQRQV 161_ WLLFE 166_ YPESS 171_ GPARG 176_ IAIVS 181_ VLVIL 186_ ISIVI 191_ FCLET 196_ LPQFR 201_ VDGRG 206_ GNNGG 211_ VSRVS 216_ PVSRG 221_ SQEEE 226_ EDEDD 231_ SYTFH 236_ HGITP 241_ GEMGT 246_ GGSSS 251_ LSTLG 256_ GSFFT 261_ DPFFL 266_ VETLC 271_ IVWFT 276_ FELLV 281_ RFSAC 286_ PSKPA 291_ FFRNI 296_ MNIID 301_ LVAIF 306_ PYFIT 311_ LGTEL 316_ VQQQE 321_ QQPAS 326_ GGGGQ 331_ NGQQA 336_ MSLAI 341_ LRVIR 346_ LVRVF 351_ RIFKL 356_ SRHSK 361_ GLQIL 366_ GKTLQ 371_ ASMRE 376_ LGLLI 381_ FFLFI 386_ GVILF 391_ SSAVY 396_ FAEAD 401_ DDDSL 406_ FPSIP 411_ DAFWW 416_ AVVTM 421_ TTVGY 426_ GDMYP 431_ MTVGG 436_ KIVGS 441_ LCAIA 446_ GVLTI 451_ ALPVP 456_ VIVSN 461_ FNYFY 466_ HRETE 471_ QEEQG 476_ QYTHV 481_ TCGQP 486_ APDLR 491_ ATDNG 496_ LGKPD 501_ FPEAN 506_ RERRP 511_ SYLPT 516_ PHRAY 521_AEKRM
1: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:14575698, PubMed:2347305). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:14575698, PubMed:2347305). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305)