Desmin
1_MSQAY 6_ SSSQR 11_ VSSYR 16_ RTFGG 21_ APGFP 26_ LGSPL 31_ SSPVF 36_ PRAGF 41_ GSKGS 46_ SSSVT 51_ SRVYQ 56_ VSRTS 61_ GGAGG 66_ LGSLR 71_ ASRLG 76_ TTRTP 81_ SSYGA 86_ GELLD 91_ FSLAD 96_ AVNQE 101_ FLTTR 106_ TNEKV 111_ ELQEL 116_ NDRFA 121_ NYIEK 126_ VRFLE 131_ QQNAA 136_ LAAEV 141_ NRLKG 146_ REPTR 151_ VAELY 156_ EEELR 161_ ELRRQ 166_ VEVLT 171_ NQRAR 176_ VDVER 181_ DNLLD 186_ DLQRL 191_ KAKLQ 196_ EEIQL 201_ KEEAE 206_ NNLAA 211_ FRADV 216_ DAATL 221_ ARIDL 226_ ERRIE 231_ SLNEE 236_ IAFLK 241_ KVHEE 246_ EIREL 251_ QAQLQ 256_ EQQVQ 261_ VEMDM 266_ SKPDL 271_ TAALR 276_ DIRAQ 281_ YETIA 286_ AKNIS 291_ EAEEW 296_ YKSKV 301_ SDLTQ 306_ AANKN 311_ NDALR 316_ QAKQE 321_ MMEYR 326_ HQIQS 331_ YTCEI 336_ DALKG 341_ TNDSL 346_ MRQMR 351_ ELEDR 356_ FASEA 361_ SGYQD 366_ NIARL 371_ EEEIR 376_ HLKDE 381_ MARHL 386_ REYQD 391_ LLNVK 396_ MALDV 401_ EIATY 406_ RKLLE 411_ GEESR 416_ INLPI 421_ QTYSA 426_ LNFRE 431_ TSPEQ 436_ RGSEV 441_ HTKKT 446_ VMIKT 451_ IETRD 456_ GEVVS 461_EATQQ
1: Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity)