Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP)
1_MPTTI 6_ EREFE 11_ ELDTQ 16_ RRWQP 21_ LYLEI 26_ RNESH 31_ DYPHR 36_ VAKFP 41_ ENRNR 46_ NRYRD 51_ VSPYD 56_ HSRVK 61_ LQNAE 66_ NDYIN 71_ ASLVD 76_ IEEAQ 81_ RSYIL 86_ TQGPL 91_ PNTCC 96_ HFWLM 101_ VWQQK 106_ TKAVV 111_ MLNRI 116_ VEKES 121_ VKCAQ 126_ YWPTD 131_ DQEML 136_ FKETG 141_ FSVKL 146_ LSEDV 151_ KSYYT 156_ VHLLQ 161_ LENIN 166_ SGETR 171_ TISHF 176_ HYTTW 181_ PDFGV 186_ PESPA 191_ SFLNF 196_ LFKVR 201_ ESGSL 206_ NPDHG 211_ PAVIH 216_ CSAGI 221_ GRSGT 226_ FSLVD 231_ TCLVL 236_ MEKGD 241_ DINIK 246_ QVLLN 251_ MRKYR 256_ MGLIQ 261_ TPDQL 266_ RFSYM 271_ AIIEG 276_ AKCIK 281_ GDSSI 286_ QKRWK 291_ ELSKE 296_ DLSPA 301_ FDHSP 306_ NKIMT 311_ EKYNG 316_ NRIGL 321_ EEEKL 326_ TGDRC 331_ TGLSS 336_ KMQDT 341_ MEENS 346_ ESALR 351_ KRIRE 356_ DRKAT 361_ TAQKV 366_ QQMKQ 371_ RLNEN 376_ ERKRK 381_ RWLYW 386_ QPILT 391_ KMGFM 396_ SVILV 401_ GAFVG 406_WTLFF
1: Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA