Tyrosine aminotransferase (TAT) (EC 2.6.1.5) (L-tyrosine:2-oxoglutarate aminotransferase)
1_MDPYM 6_ IQMSS 11_ KGNLP 16_ SILDV 21_ HVNVG 26_ GRSSV 31_ PGKMK 36_ GRKAR 41_ WSVRP 46_ SDMAK 51_ KTFNP 56_ IRAIV 61_ DNMKV 66_ KPNPN 71_ KTMIS 76_ LSIGD 81_ PTVFG 86_ NLPTD 91_ PEVTQ 96_ AMKDA 101_ LDSGK 106_ YNGYA 111_ PSIGF 116_ LSSRE 121_ EIASY 126_ YHCPE 131_ APLEA 136_ KDVIL 141_ TSGCS 146_ QAIDL 151_ CLAVL 156_ ANPGQ 161_ NILVP 166_ RPGFS 171_ LYKTL 176_ AESMG 181_ IEVKL 186_ YNLLP 191_ EKSWE 196_ IDLKQ 201_ LEYLI 206_ DEKTA 211_ CLIVN 216_ NPSNP 221_ CGSVF 226_ SKRHL 231_ QKILA 236_ VAARQ 241_ CVPIL 246_ ADEIY 251_ GDMVF 256_ SDCKY 261_ EPLAT 266_ LSTDV 271_ PILSC 276_ GGLAK 281_ RWLVP 286_ GWRLG 291_ WILIH 296_ DRRDI 301_ FGNEI 306_ RDGLV 311_ KLSQR 316_ ILGPC 321_ TIVQG 326_ ALKSI 331_ LCRTP 336_ GEFYH 341_ NTLSF 346_ LKSNA 351_ DLCYG 356_ ALAAI 361_ PGLRP 366_ VRPSG 371_ AMYLM 376_ VGIEM 381_ EHFPE 386_ FENDV 391_ EFTER 396_ LVAEQ 401_ SVHCL 406_ PATCF 411_ EYPNF 416_ IRVVI 421_ TVPEV 426_ MMLEA 431_ CSRIQ 436_ EFCEQ 441_ HYHCA 446_EGSQE
1: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine