Neuronal acetylcholine receptor subunit beta-2
1_MARRC 6_ GPVAL 11_ LLGFG 16_ LLRLC 21_ SGVWG 26_ TDTEE 31_ RLVEH 36_ LLDPS 41_ RYNKL 46_ IRPAT 51_ NGSEL 56_ VTVQL 61_ MVSLA 66_ QLISV 71_ HEREQ 76_ IMTTN 81_ VWLTQ 86_ EWEDY 91_ RLTWK 96_ PEEFD 101_ NMKKV 106_ RLPSK 111_ HIWLP 116_ DVVLY 121_ NNADG 126_ MYEVS 131_ FYSNA 136_ VVSYD 141_ GSIFW 146_ LPPAI 151_ YKSAC 156_ KIEVK 161_ HFPFD 166_ QQNCT 171_ MKFRS 176_ WTYDR 181_ TEIDL 186_ VLKSE 191_ VASLD 196_ DFTPS 201_ GEWDI 206_ VALPG 211_ RRNEN 216_ PDDST 221_ YVDIT 226_ YDFII 231_ RRKPL 236_ FYTIN 241_ LIIPC 246_ VLITS 251_ LAILV 256_ FYLPS 261_ DCGEK 266_ MTLCI 271_ SVLLA 276_ LTVFL 281_ LLISK 286_ IVPPT 291_ SLDVP 296_ LVGKY 301_ LMFTM 306_ VLVTF 311_ SIVTS 316_ VCVLN 321_ VHHRS 326_ PTTHT 331_ MAPWV 336_ KVVFL 341_ EKLPA 346_ LLFMQ 351_ QPRHH 356_ CARQR 361_ LRLRR 366_ RQRER 371_ EGAGA 376_ LFFRE 381_ APGAD 386_ SCTCF 391_ VNRAS 396_ VQGLA 401_ GAFGA 406_ EPAPV 411_ AGPGR 416_ SGEPC 421_ GCGLR 426_ EAVDG 431_ VRFIA 436_ DHMRS 441_ EDDDQ 446_ SVSED 451_ WKYVA 456_ MVIDR 461_ LFLWI 466_ FVFVC 471_ VFGTI 476_ GMFLQ 481_ PLFQN 486_ YTTTT 491_ FLHSD 496_HSAPS
1: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:22361591, PubMed:27698419, PubMed:29720657, PubMed:38454578). CHRNB2 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3, CHRNA4 and CHRNA6, as well as CHRNA5 and CHRNB3 as accesory subunits (PubMed:16835356, PubMed:20881005, PubMed:22361591, PubMed:27698419, PubMed:29720657, PubMed:38454578, PubMed:8663494). Found in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation by divalent cation (PubMed:27698419, PubMed:29720657, PubMed:38454578). Heteropentameric channels with CHRNA6 and CHRNA4 exhibit high sensitivity to ACh and nicotine and are predominantly expressed in only a few brain areas, including dopaminergic neurons, norepirephrine neurons and cells of the visual system. nAChrs containing CHRNA6 subunits mediate endogenous cholinergic modulation of dopamine and gamma-aminobutyric acid (GABA) release in response to nicotine at nerve terminals (By similarity). Also forms functional nAChRs with other subunits such as CHRNA7:CHRNB2, mainly expressed in basal forebrain cholinergic neurons (PubMed:33239400, PubMed:38161283)