Endoglin (CD antigen CD105)
1_MDRGT 6_ LPLAV 11_ ALLLA 16_ SCSLS 21_ PTSLA 26_ ETVHC 31_ DLQPV 36_ GPERG 41_ EVTYT 46_ TSQVS 51_ KGCVA 56_ QAPNA 61_ ILEVH 66_ VLFLE 71_ FPTGP 76_ SQLEL 81_ TLQAS 86_ KQNGT 91_ WPREV 96_ LLVLS 101_ VNSSV 106_ FLHLQ 111_ ALGIP 116_ LHLAY 121_ NSSLV 126_ TFQEP 131_ PGVNT 136_ TELPS 141_ FPKTQ 146_ ILEWA 151_ AERGP 156_ ITSAA 161_ ELNDP 166_ QSILL 171_ RLGQA 176_ QGSLS 181_ FCMLE 186_ ASQDM 191_ GRTLE 196_ WRPRT 201_ PALVR 206_ GCHLE 211_ GVAGH 216_ KEAHI 221_ LRVLP 226_ GHSAG 231_ PRTVT 236_ VKVEL 241_ SCAPG 246_ DLDAV 251_ LILQG 256_ PPYVS 261_ WLIDA 266_ NHNMQ 271_ IWTTG 276_ EYSFK 281_ IFPEK 286_ NIRGF 291_ KLPDT 296_ PQGLL 301_ GEARM 306_ LNASI 311_ VASFV 316_ ELPLA 321_ SIVSL 326_ HASSC 331_ GGRLQ 336_ TSPAP 341_ IQTTP 346_ PKDTC 351_ SPELL 356_ MSLIQ 361_ TKCAD 366_ DAMTL 371_ VLKKE 376_ LVAHL 381_ KCTIT 386_ GLTFW 391_ DPSCE 396_ AEDRG 401_ DKFVL 406_ RSAYS 411_ SCGMQ 416_ VSASM 421_ ISNEA 426_ VVNIL 431_ SSSSP 436_ QRKKV 441_ HCLNM 446_ DSLSF 451_ QLGLY 456_ LSPHF 461_ LQASN 466_ TIEPG 471_ QQSFV 476_ QVRVS 481_ PSVSE 486_ FLLQL 491_ DSCHL 496_ DLGPE 501_ GGTVE 506_ LIQGR 511_ AAKGN 516_ CVSLL 521_ SPSPE 526_ GDPRF 531_ SFLLH 536_ FYTVP 541_ IPKTG 546_ TLSCT 551_ VALRP 556_ KTGSQ 561_ DQEVH 566_ RTVFM 571_ RLNII 576_ SPDLS 581_ GCTSK 586_ GLVLP 591_ AVLGI 596_ TFGAF 601_ LIGAL 606_ LTAAL 611_ WYIYS 616_ HTRSP 621_ SKREP 626_ VVAVA 631_ APASS 636_ ESSST 641_ NHSIG 646_ STQST 651_PCSTS
1: Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:21737454, PubMed:22347366, PubMed:23300529, PubMed:8370410). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529)