Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)
1_MSGYS 6_ SDRDR 11_ GRDRG 16_ FGAPR 21_ FGGSR 26_ AGPLS 31_ GKKFG 36_ NPGEK 41_ LVKKK 46_ WNLDE 51_ LPKFE 56_ KNFYQ 61_ EHPDL 66_ ARRTA 71_ QEVET 76_ YRRSK 81_ EITVR 86_ GHNCP 91_ KPVLN 96_ FYEAN 101_ FPANV 106_ MDVIA 111_ RQNFT 116_ EPTAI 121_ QAQGW 126_ PVALS 131_ GLDMV 136_ GVAQT 141_ GSGKT 146_ LSYLL 151_ PAIVH 156_ INHQP 161_ FLERG 166_ DGPIC 171_ LVLAP 176_ TRELA 181_ QQVQQ 186_ VAAEY 191_ CRACR 196_ LKSTC 201_ IYGGA 206_ PKGPQ 211_ IRDLE 216_ RGVEI 221_ CIATP 226_ GRLID 231_ FLECG 236_ KTNLR 241_ RTTYL 246_ VLDEA 251_ DRMLD 256_ MGFEP 261_ QIRKI 266_ VDQIR 271_ PDRQT 276_ LMWSA 281_ TWPKE 286_ VRQLA 291_ EDFLK 296_ DYIHI 301_ NIGAL 306_ ELSAN 311_ HNILQ 316_ IVDVC 321_ HDVEK 326_ DEKLI 331_ RLMEE 336_ IMSEK 341_ ENKTI 346_ VFVET 351_ KRRCD 356_ ELTRK 361_ MRRDG 366_ WPAMG 371_ IHGDK 376_ SQQER 381_ DWVLN 386_ EFKHG 391_ KAPIL 396_ IATDV 401_ ASRGL 406_ DVEDV 411_ KFVIN 416_ YDYPN 421_ SSEDY 426_ IHRIG 431_ RTARS 436_ TKTGT 441_ AYTFF 446_ TPNNI 451_ KQVSD 456_ LISVL 461_ REANQ 466_ AINPK 471_ LLQLV 476_ EDRGS 481_ GRSRG 486_ RGGMK 491_ DDRRD 496_ RYSAG 501_ KRGGF 506_ NTFRD 511_ RENYD 516_ RGYSS 521_ LLKRD 526_ FGAKT 531_ QNGVY 536_ SAANY 541_ TNGSF 546_ GSNFV 551_ SAGIQ 556_ TSFRT 561_ GNPTG 566_ TYQNG 571_ YDSTQ 576_ QYGSN 581_ VPNMH 586_ NGMNQ 591_ QAYAY 596_ PATAA 601_ APMIG 606_YPMPT
1: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as a transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms