ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase)
1_MAAVD 6_ LEKLR 11_ ASGAG 16_ KAIGV 21_ LTSGG 26_ DAQGM 31_ NAAVR 36_ AVTRM 41_ GIYVG 46_ AKVFL 51_ IYEGY 56_ EGLVE 61_ GGENI 66_ KQANW 71_ LSVSN 76_ IIQLG 81_ GTIIG 86_ SARCK 91_ AFTTR 96_ EGRRA 101_ AAYNL 106_ VQHGI 111_ TNLCV 116_ IGGDG 121_ SLTGA 126_ NIFRS 131_ EWGSL 136_ LEELV 141_ AEGKI 146_ SETTA 151_ RTYSH 156_ LNIAG 161_ LVGSI 166_ DNDFC 171_ GTDMT 176_ IGTDS 181_ ALHRI 186_ MEVID 191_ AITTT 196_ AQSHQ 201_ RTFVL 206_ EVMGR 211_ HCGYL 216_ ALVSA 221_ LASGA 226_ DWLFI 231_ PEAPP 236_ EDGWE 241_ NFMCE 246_ RLGET 251_ RSRGS 256_ RLNII 261_ IIAEG 266_ AIDRN 271_ GKPIS 276_ SSYVK 281_ DLVVQ 286_ RLGFD 291_ TRVTV 296_ LGHVQ 301_ RGGTP 306_ SAFDR 311_ ILSSK 316_ MGMEA 321_ VMALL 326_ EATPD 331_ TPACV 336_ VTLSG 341_ NQSVR 346_ LPLME 351_ CVQMT 356_ KEVQK 361_ AMDDK 366_ RFDEA 371_ TQLRG 376_ GSFEN 381_ NWNIY 386_ KLLAH 391_ QKPPK 396_ EKSNF 401_ SLAIL 406_ NVGAP 411_ AAGMN 416_ AAVRS 421_ AVRTG 426_ ISHGH 431_ TVYVV 436_ HDGFE 441_ GLAKG 446_ QVQEV 451_ GWHDV 456_ AGWLG 461_ RGGSM 466_ LGTKR 471_ TLPKG 476_ QLESI 481_ VENIR 486_ IYGIH 491_ ALLVV 496_ GGFEA 501_ YEGVL 506_ QLVEA 511_ RGRYE 516_ ELCIV 521_ MCVIP 526_ ATISN 531_ NVPGT 536_ DFSLG 541_ SDTAV 546_ NAAME 551_ SCDRI 556_ KQSAS 561_ GTKRR 566_ VFIVE 571_ TMGGY 576_ CGYLA 581_ TVTGI 586_ AVGAD 591_ AAYVF 596_ EDPFN 601_ IHDLK 606_ VNVEH 611_ MTEKM 616_ KTDIQ 621_ RGLVL 626_ RNEKC 631_ HDYYT 636_ TEFLY 641_ NLYSS 646_ EGKGV 651_ FDCRT 656_ NVLGH 661_ LQQGG 666_ APTPF 671_ DRNYG 676_ TKLGV 681_ KAMLW 686_ LSEKL 691_ REVYR 696_ KGRVF 701_ ANAPD 706_ SACVI 711_ GLKKK 716_ AVAFS 721_ PVTEL 726_ KKDTD 731_ FEHRM 736_ PREQW 741_ WLSLR 746_ LMLKM 751_ LAQYR 756_ ISMAA 761_ YVSGE 766_ LEHVT 771_RRTLS
1: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity)