Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) [Cleaved into: Ganglioside GM2 activator isoform short]
1_MQSLM 6_ QAPLL 11_ IALGL 16_ LLAAP 21_ AQAHL 26_ KKPSQ 31_ LSSFS 36_ WDNCD 41_ EGKDP 46_ AVIRS 51_ LTLEP 56_ DPIIV 61_ PGNVT 66_ LSVMG 71_ STSVP 76_ LSSPL 81_ KVDLV 86_ LEKEV 91_ AGLWI 96_ KIPCT 101_ DYIGS 106_ CTFEH 111_ FCDVL 116_ DMLIP 121_ TGEPC 126_ PEPLR 131_ TYGLP 136_ CHCPF 141_ KEGTY 146_ SLPKS 151_ EFVVP 156_ DLELP 161_ SWLTT 166_ GNYRI 171_ ESVLS 176_ SSGKR 181_ LGCIK 186_IAASL
1: The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 (By similarity). Has cholesterol transfer activity (PubMed:17552909)