Gene name: CR1

Uniprot entry:

P17927

Protein names:

Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)

Protein sequence:

1_MGASS 6_ PRSPE 11_ PVGPP 16_ APGLP 21_ FCCGG 26_ SLLAV 31_ VVLLA 36_ LPVAW 41_ GQCNA 46_ PEWLP 51_ FARPT 56_ NLTDE 61_ FEFPI 66_ GTYLN 71_ YECRP 76_ GYSGR 81_ PFSII 86_ CLKNS 91_ VWTGA 96_ KDRCR 101_ RKSCR 106_ NPPDP 111_ VNGMV 116_ HVIKG 121_ IQFGS 126_ QIKYS 131_ CTKGY 136_ RLIGS 141_ SSATC 146_ IISGD 151_ TVIWD 156_ NETPI 161_ CDRIP 166_ CGLPP 171_ TITNG 176_ DFIST 181_ NRENF 186_ HYGSV 191_ VTYRC 196_ NPGSG 201_ GRKVF 206_ ELVGE 211_ PSIYC 216_ TSNDD 221_ QVGIW 226_ SGPAP 231_ QCIIP 236_ NKCTP 241_ PNVEN 246_ GILVS 251_ DNRSL 256_ FSLNE 261_ VVEFR 266_ CQPGF 271_ VMKGP 276_ RRVKC 281_ QALNK 286_ WEPEL 291_ PSCSR 296_ VCQPP 301_ PDVLH 306_ AERTQ 311_ RDKDN 316_ FSPGQ 321_ EVFYS 326_ CEPGY 331_ DLRGA 336_ ASMRC 341_ TPQGD 346_ WSPAA 351_ PTCEV 356_ KSCDD 361_ FMGQL 366_ LNGRV 371_ LFPVN 376_ LQLGA 381_ KVDFV 386_ CDEGF 391_ QLKGS 396_ SASYC 401_ VLAGM 406_ ESLWN 411_ SSVPV 416_ CEQIF 421_ CPSPP 426_ VIPNG 431_ RHTGK 436_ PLEVF 441_ PFGKT 446_ VNYTC 451_ DPHPD 456_ RGTSF 461_ DLIGE 466_ STIRC 471_ TSDPQ 476_ GNGVW 481_ SSPAP 486_ RCGIL 491_ GHCQA 496_ PDHFL 501_ FAKLK 506_ TQTNA 511_ SDFPI 516_ GTSLK 521_ YECRP 526_ EYYGR 531_ PFSIT 536_ CLDNL 541_ VWSSP 546_ KDVCK 551_ RKSCK 556_ TPPDP 561_ VNGMV 566_ HVITD 571_ IQVGS 576_ RINYS 581_ CTTGH 586_ RLIGH 591_ SSAEC 596_ ILSGN 601_ AAHWS 606_ TKPPI 611_ CQRIP 616_ CGLPP 621_ TIANG 626_ DFIST 631_ NRENF 636_ HYGSV 641_ VTYRC 646_ NPGSG 651_ GRKVF 656_ ELVGE 661_ PSIYC 666_ TSNDD 671_ QVGIW 676_ SGPAP 681_ QCIIP 686_ NKCTP 691_ PNVEN 696_ GILVS 701_ DNRSL 706_ FSLNE 711_ VVEFR 716_ CQPGF 721_ VMKGP 726_ RRVKC 731_ QALNK 736_ WEPEL 741_ PSCSR 746_ VCQPP 751_ PDVLH 756_ AERTQ 761_ RDKDN 766_ FSPGQ 771_ EVFYS 776_ CEPGY 781_ DLRGA 786_ ASMRC 791_ TPQGD 796_ WSPAA 801_ PTCEV 806_ KSCDD 811_ FMGQL 816_ LNGRV 821_ LFPVN 826_ LQLGA 831_ KVDFV 836_ CDEGF 841_ QLKGS 846_ SASYC 851_ VLAGM 856_ ESLWN 861_ SSVPV 866_ CEQIF 871_ CPSPP 876_ VIPNG 881_ RHTGK 886_ PLEVF 891_ PFGKA 896_ VNYTC 901_ DPHPD 906_ RGTSF 911_ DLIGE 916_ STIRC 921_ TSDPQ 926_ GNGVW 931_ SSPAP 936_ RCGIL 941_ GHCQA 946_ PDHFL 951_ FAKLK 956_ TQTNA 961_ SDFPI 966_ GTSLK 971_ YECRP 976_ EYYGR 981_ PFSIT 986_ CLDNL 991_ VWSSP 996_ KDVCK 1001_ RKSCK 1006_ TPPDP 1011_ VNGMV 1016_ HVITD 1021_ IQVGS 1026_ RINYS 1031_ CTTGH 1036_ RLIGH 1041_ SSAEC 1046_ ILSGN 1051_ TAHWS 1056_ TKPPI 1061_ CQRIP 1066_ CGLPP 1071_ TIANG 1076_ DFIST 1081_ NRENF 1086_ HYGSV 1091_ VTYRC 1096_ NLGSR 1101_ GRKVF 1106_ ELVGE 1111_ PSIYC 1116_ TSNDD 1121_ QVGIW 1126_ SGPAP 1131_ QCIIP 1136_ NKCTP 1141_ PNVEN 1146_ GILVS 1151_ DNRSL 1156_ FSLNE 1161_ VVEFR 1166_ CQPGF 1171_ VMKGP 1176_ RRVKC 1181_ QALNK 1186_ WEPEL 1191_ PSCSR 1196_ VCQPP 1201_ PEILH 1206_ GEHTP 1211_ SHQDN 1216_ FSPGQ 1221_ EVFYS 1226_ CEPGY 1231_ DLRGA 1236_ ASLHC 1241_ TPQGD 1246_ WSPEA 1251_ PRCAV 1256_ KSCDD 1261_ FLGQL 1266_ PHGRV 1271_ LFPLN 1276_ LQLGA 1281_ KVSFV 1286_ CDEGF 1291_ RLKGS 1296_ SVSHC 1301_ VLVGM 1306_ RSLWN 1311_ NSVPV 1316_ CEHIF 1321_ CPNPP 1326_ AILNG 1331_ RHTGT 1336_ PSGDI 1341_ PYGKE 1346_ ISYTC 1351_ DPHPD 1356_ RGMTF 1361_ NLIGE 1366_ STIRC 1371_ TSDPH 1376_ GNGVW 1381_ SSPAP 1386_ RCELS 1391_ VRAGH 1396_ CKTPE 1401_ QFPFA 1406_ SPTIP 1411_ INDFE 1416_ FPVGT 1421_ SLNYE 1426_ CRPGY 1431_ FGKMF 1436_ SISCL 1441_ ENLVW 1446_ SSVED 1451_ NCRRK 1456_ SCGPP 1461_ PEPFN 1466_ GMVHI 1471_ NTDTQ 1476_ FGSTV 1481_ NYSCN 1486_ EGFRL 1491_ IGSPS 1496_ TTCLV 1501_ SGNNV 1506_ TWDKK 1511_ APICE 1516_ IISCE 1521_ PPPTI 1526_ SNGDF 1531_ YSNNR 1536_ TSFHN 1541_ GTVVT 1546_ YQCHT 1551_ GPDGE 1556_ QLFEL 1561_ VGERS 1566_ IYCTS 1571_ KDDQV 1576_ GVWSS 1581_ PPPRC 1586_ ISTNK 1591_ CTAPE 1596_ VENAI 1601_ RVPGN 1606_ RSFFS 1611_ LTEII 1616_ RFRCQ 1621_ PGFVM 1626_ VGSHT 1631_ VQCQT 1636_ NGRWG 1641_ PKLPH 1646_ CSRVC 1651_ QPPPE 1656_ ILHGE 1661_ HTLSH 1666_ QDNFS 1671_ PGQEV 1676_ FYSCE 1681_ PSYDL 1686_ RGAAS 1691_ LHCTP 1696_ QGDWS 1701_ PEAPR 1706_ CTVKS 1711_ CDDFL 1716_ GQLPH 1721_ GRVLL 1726_ PLNLQ 1731_ LGAKV 1736_ SFVCD 1741_ EGFRL 1746_ KGRSA 1751_ SHCVL 1756_ AGMKA 1761_ LWNSS 1766_ VPVCE 1771_ QIFCP 1776_ NPPAI 1781_ LNGRH 1786_ TGTPF 1791_ GDIPY 1796_ GKEIS 1801_ YACDT 1806_ HPDRG 1811_ MTFNL 1816_ IGESS 1821_ IRCTS 1826_ DPQGN 1831_ GVWSS 1836_ PAPRC 1841_ ELSVP 1846_ AACPH 1851_ PPKIQ 1856_ NGHYI 1861_ GGHVS 1866_ LYLPG 1871_ MTISY 1876_ ICDPG 1881_ YLLVG 1886_ KGFIF 1891_ CTDQG 1896_ IWSQL 1901_ DHYCK 1906_ EVNCS 1911_ FPLFM 1916_ NGISK 1921_ ELEMK 1926_ KVYHY 1931_ GDYVT 1936_ LKCED 1941_ GYTLE 1946_ GSPWS 1951_ QCQAD 1956_ DRWDP 1961_ PLAKC 1966_ TSRTH 1971_ DALIV 1976_ GTLSG 1981_ TIFFI 1986_ LLIIF 1991_ LSWII 1996_ LKHRK 2001_ GNNAH 2006_ ENPKE 2011_ VAIHL 2016_ HSQGG 2021_ SSVHP 2026_ RTLQT 2031_NEENS

Protein annotations

Protein functions:

1: Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Also acts in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728)

2: (Microbial infection) Acts as a receptor for Epstein-Barr virus