Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen)
1_MADNF 6_ SLHDA 11_ LSGSG 16_ NPNPQ 21_ GWPGA 26_ WGNQP 31_ AGAGG 36_ YPGAS 41_ YPGAY 46_ PGQAP 51_ PGAYP 56_ GQAPP 61_ GAYPG 66_ APGAY 71_ PGAPA 76_ PGVYP 81_ GPPSG 86_ PGAYP 91_ SSGQP 96_ SATGA 101_ YPATG 106_ PYGAP 111_ AGPLI 116_ VPYNL 121_ PLPGG 126_ VVPRM 131_ LITIL 136_ GTVKP 141_ NANRI 146_ ALDFQ 151_ RGNDV 156_ AFHFN 161_ PRFNE 166_ NNRRV 171_ IVCNT 176_ KLDNN 181_ WGREE 186_ RQSVF 191_ PFESG 196_ KPFKI 201_ QVLVE 206_ PDHFK 211_ VAVND 216_ AHLLQ 221_ YNHRV 226_ KKLNE 231_ ISKLG 236_ ISGDI 241_DLTSA
1: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes