Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
1_MVSYW 6_ DTGVL 11_ LCALL 16_ SCLLL 21_ TGSSS 26_ GSKLK 31_ DPELS 36_ LKGTQ 41_ HIMQA 46_ GQTLH 51_ LQCRG 56_ EAAHK 61_ WSLPE 66_ MVSKE 71_ SERLS 76_ ITKSA 81_ CGRNG 86_ KQFCS 91_ TLTLN 96_ TAQAN 101_ HTGFY 106_ SCKYL 111_ AVPTS 116_ KKKET 121_ ESAIY 126_ IFISD 131_ TGRPF 136_ VEMYS 141_ EIPEI 146_ IHMTE 151_ GRELV 156_ IPCRV 161_ TSPNI 166_ TVTLK 171_ KFPLD 176_ TLIPD 181_ GKRII 186_ WDSRK 191_ GFIIS 196_ NATYK 201_ EIGLL 206_ TCEAT 211_ VNGHL 216_ YKTNY 221_ LTHRQ 226_ TNTII 231_ DVQIS 236_ TPRPV 241_ KLLRG 246_ HTLVL 251_ NCTAT 256_ TPLNT 261_ RVQMT 266_ WSYPD 271_ EKNKR 276_ ASVRR 281_ RIDQS 286_ NSHAN 291_ IFYSV 296_ LTIDK 301_ MQNKD 306_ KGLYT 311_ CRVRS 316_ GPSFK 321_ SVNTS 326_ VHIYD 331_ KAFIT 336_ VKHRK 341_ QQVLE 346_ TVAGK 351_ RSYRL 356_ SMKVK 361_ AFPSP 366_ EVVWL 371_ KDGLP 376_ ATEKS 381_ ARYLT 386_ RGYSL 391_ IIKDV 396_ TEEDA 401_ GNYTI 406_ LLSIK 411_ QSNVF 416_ KNLTA 421_ TLIVN 426_ VKPQI 431_ YEKAV 436_ SSFPD 441_ PALYP 446_ LGSRQ 451_ ILTCT 456_ AYGIP 461_ QPTIK 466_ WFWHP 471_ CNHNH 476_ SEARC 481_ DFCSN 486_ NEESF 491_ ILDAD 496_ SNMGN 501_ RIESI 506_ TQRMA 511_ IIEGK 516_ NKMAS 521_ TLVVA 526_ DSRIS 531_ GIYIC 536_ IASNK 541_ VGTVG 546_ RNISF 551_ YITDV 556_ PNGFH 561_ VNLEK 566_ MPTEG 571_ EDLKL 576_ SCTVN 581_ KFLYR 586_ DVTWI 591_ LLRTV 596_ NNRTM 601_ HYSIS 606_ KQKMA 611_ ITKEH 616_ SITLN 621_ LTIMN 626_ VSLQD 631_ SGTYA 636_ CRARN 641_ VYTGE 646_ EILQK 651_ KEITI 656_ RDQEA 661_ PYLLR 666_ NLSDH 671_ TVAIS 676_ SSTTL 681_ DCHAN 686_ GVPEP 691_ QITWF 696_ KNNHK 701_ IQQEP 706_ GIILG 711_ PGSST 716_ LFIER 721_ VTEED 726_ EGVYH 731_ CKATN 736_ QKGSV 741_ ESSAY 746_ LTVQG 751_ TSDKS 756_ NLELI 761_ TLTCT 766_ CVAAT 771_ LFWLL 776_ LTLFI 781_ RKMKR 786_ SSSEI 791_ KTDYL 796_ SIIMD 801_ PDEVP 806_ LDEQC 811_ ERLPY 816_ DASKW 821_ EFARE 826_ RLKLG 831_ KSLGR 836_ GAFGK 841_ VVQAS 846_ AFGIK 851_ KSPTC 856_ RTVAV 861_ KMLKE 866_ GATAS 871_ EYKAL 876_ MTELK 881_ ILTHI 886_ GHHLN 891_ VVNLL 896_ GACTK 901_ QGGPL 906_ MVIVE 911_ YCKYG 916_ NLSNY 921_ LKSKR 926_ DLFFL 931_ NKDAA 936_ LHMEP 941_ KKEKM 946_ EPGLE 951_ QGKKP 956_ RLDSV 961_ TSSES 966_ FASSG 971_ FQEDK 976_ SLSDV 981_ EEEED 986_ SDGFY 991_ KEPIT 996_ MEDLI 1001_ SYSFQ 1006_ VARGM 1011_ EFLSS 1016_ RKCIH 1021_ RDLAA 1026_ RNILL 1031_ SENNV 1036_ VKICD 1041_ FGLAR 1046_ DIYKN 1051_ PDYVR 1056_ KGDTR 1061_ LPLKW 1066_ MAPES 1071_ IFDKI 1076_ YSTKS 1081_ DVWSY 1086_ GVLLW 1091_ EIFSL 1096_ GGSPY 1101_ PGVQM 1106_ DEDFC 1111_ SRLRE 1116_ GMRMR 1121_ APEYS 1126_ TPEIY 1131_ QIMLD 1136_ CWHRD 1141_ PKERP 1146_ RFAEL 1151_ VEKLG 1156_ DLLQA 1161_ NVQQD 1166_ GKDYI 1171_ PINAI 1176_ LTGNS 1181_ GFTYS 1186_ TPAFS 1191_ EDFFK 1196_ ESISA 1201_ PKFNS 1206_ GSSDD 1211_ VRYVN 1216_ AFKFM 1221_ SLERI 1226_ KTFEE 1231_ LLPNA 1236_ TSMFD 1241_ DYQGD 1246_ SSTLL 1251_ ASPML 1256_ KRFTW 1261_ TDSKP 1266_ KASLK 1271_ IDLRV 1276_ TSKSK 1281_ ESGLS 1286_ DVSRP 1291_ SFCHS 1296_ SCGHV 1301_ SEGKR 1306_ RFTYD 1311_ HAELE 1316_ RKIAC 1321_ CSPPP 1326_ DYNSV 1331_VLYST
1: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275)
2: Phosphorylates PLCG
3: May function as decoy receptor for VEGFA
4: May function as decoy receptor for VEGFA
5: May function as decoy receptor for VEGFA
6: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion