26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
1_MNLLP 6_ NIESP 11_ VTRQE 16_ KMATV 21_ WDEAE 26_ QDGIG 31_ EEVLK 36_ MSTEE 41_ IIQRT 46_ RLLDS 51_ EIKIM 56_ KSEVL 61_ RVTHE 66_ LQAMK 71_ DKIKE 76_ NSEKI 81_ KVNKT 86_ LPYLV 91_ SNVIE 96_ LLDVD 101_ PNDQE 106_ EDGAN 111_ IDLDS 116_ QRKGK 121_ CAVIK 126_ TSTRQ 131_ TYFLP 136_ VIGLV 141_ DAEKL 146_ KPGDL 151_ VGVNK 156_ DSYLI 161_ LETLP 166_ TEYDS 171_ RVKAM 176_ EVDER 181_ PTEQY 186_ SDIGG 191_ LDKQI 196_ QELVE 201_ AIVLP 206_ MNHKE 211_ KFENL 216_ GIQPP 221_ KGVLM 226_ YGPPG 231_ TGKTL 236_ LARAC 241_ AAQTK 246_ ATFLK 251_ LAGPQ 256_ LVQMF 261_ IGDGA 266_ KLVRD 271_ AFALA 276_ KEKAP 281_ SIIFI 286_ DELDA 291_ IGTKR 296_ FDSEK 301_ AGDRE 306_ VQRTM 311_ LELLN 316_ QLDGF 321_ QPNTQ 326_ VKVIA 331_ ATNRV 336_ DILDP 341_ ALLRS 346_ GRLDR 351_ KIEFP 356_ MPNEE 361_ ARARI 366_ MQIHS 371_ RKMNV 376_ SPDVN 381_ YEELA 386_ RCTDD 391_ FNGAQ 396_ CKAVC 401_ VEAGM 406_ IALRR 411_ GATEL 416_ THEDY 421_ MEGIL 426_ EVQAK 431_KKANL
1: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides