Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
1_MEMEK 6_ EFEQI 11_ DKSGS 16_ WAAIY 21_ QDIRH 26_ EASDF 31_ PCRVA 36_ KLPKN 41_ KNRNR 46_ YRDVS 51_ PFDHS 56_ RIKLH 61_ QEDND 66_ YINAS 71_ LIKME 76_ EAQRS 81_ YILTQ 86_ GPLPN 91_ TCGHF 96_ WEMVW 101_ EQKSR 106_ GVVML 111_ NRVME 116_ KGSLK 121_ CAQYW 126_ PQKEE 131_ KEMIF 136_ EDTNL 141_ KLTLI 146_ SEDIK 151_ SYYTV 156_ RQLEL 161_ ENLTT 166_ QETRE 171_ ILHFH 176_ YTTWP 181_ DFGVP 186_ ESPAS 191_ FLNFL 196_ FKVRE 201_ SGSLS 206_ PEHGP 211_ VVVHC 216_ SAGIG 221_ RSGTF 226_ CLADT 231_ CLLLM 236_ DKRKD 241_ PSSVD 246_ IKKVL 251_ LEMRK 256_ FRMGL 261_ IQTAD 266_ QLRFS 271_ YLAVI 276_ EGAKF 281_ IMGDS 286_ SVQDQ 291_ WKELS 296_ HEDLE 301_ PPPEH 306_ IPPPP 311_ RPPKR 316_ ILEPH 321_ NGKCR 326_ EFFPN 331_ HQWVK 336_ EETQE 341_ DKDCP 346_ IKEEK 351_ GSPLN 356_ AAPYG 361_ IESMS 366_ QDTEV 371_ RSRVV 376_ GGSLR 381_ GAQAA 386_ SPAKG 391_ EPSLP 396_ EKDED 401_ HALSY 406_ WKPFL 411_ VNMCV 416_ ATVLT 421_ AGAYL 426_CYRFL
1: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET