Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2)
1_MLPRV 6_ GCPAL 11_ PLPPP 16_ PLLPL 21_ LLLLL 26_ GASGG 31_ GGGAR 36_ AEVLF 41_ RCPPC 46_ TPERL 51_ AACGP 56_ PPVAP 61_ PAAVA 66_ AVAGG 71_ ARMPC 76_ AELVR 81_ EPGCG 86_ CCSVC 91_ ARLEG 96_ EACGV 101_ YTPRC 106_ GQGLR 111_ CYPHP 116_ GSELP 121_ LQALV 126_ MGEGT 131_ CEKRR 136_ DAEYG 141_ ASPEQ 146_ VADNG 151_ DDHSE 156_ GGLVE 161_ NHVDS 166_ TMNML 171_ GGGGS 176_ AGRKP 181_ LKSGM 186_ KELAV 191_ FREKV 196_ TEQHR 201_ QMGKG 206_ GKHHL 211_ GLEEP 216_ KKLRP 221_ PPART 226_ PCQQE 231_ LDQVL 236_ ERIST 241_ MRLPD 246_ ERGPL 251_ EHLYS 256_ LHIPN 261_ CDKHG 266_ LYNLK 271_ QCKMS 276_ LNGQR 281_ GECWC 286_ VNPNT 291_ GKLIQ 296_ GAPTI 301_ RGDPE 306_ CHLFY 311_ NEQQE 316_ARGVH
1: Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18563800, PubMed:38796567). Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation (PubMed:22869525). Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif (PubMed:16569642). Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells (PubMed:26076738). Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury (PubMed:38796567)