Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa)
1_MHVRS 6_ LRAAA 11_ PHSFV 16_ ALWAP 21_ LFLLR 26_ SALAD 31_ FSLDN 36_ EVHSS 41_ FIHRR 46_ LRSQE 51_ RREMQ 56_ REILS 61_ ILGLP 66_ HRPRP 71_ HLQGK 76_ HNSAP 81_ MFMLD 86_ LYNAM 91_ AVEEG 96_ GGPGG 101_ QGFSY 106_ PYKAV 111_ FSTQG 116_ PPLAS 121_ LQDSH 126_ FLTDA 131_ DMVMS 136_ FVNLV 141_ EHDKE 146_ FFHPR 151_ YHHRE 156_ FRFDL 161_ SKIPE 166_ GEAVT 171_ AAEFR 176_ IYKDY 181_ IRERF 186_ DNETF 191_ RISVY 196_ QVLQE 201_ HLGRE 206_ SDLFL 211_ LDSRT 216_ LWASE 221_ EGWLV 226_ FDITA 231_ TSNHW 236_ VVNPR 241_ HNLGL 246_ QLSVE 251_ TLDGQ 256_ SINPK 261_ LAGLI 266_ GRHGP 271_ QNKQP 276_ FMVAF 281_ FKATE 286_ VHFRS 291_ IRSTG 296_ SKQRS 301_ QNRSK 306_ TPKNQ 311_ EALRM 316_ ANVAE 321_ NSSSD 326_ QRQAC 331_ KKHEL 336_ YVSFR 341_ DLGWQ 346_ DWIIA 351_ PEGYA 356_ AYYCE 361_ GECAF 366_ PLNSY 371_ MNATN 376_ HAIVQ 381_ TLVHF 386_ INPET 391_ VPKPC 396_ CAPTQ 401_ LNAIS 406_ VLYFD 411_ DSSNV 416_ ILKKY 421_ RNMVV 426_RACGC
1: Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:12667445, PubMed:9748228). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509)