Alpha-2B adrenergic receptor (Alpha-2 adrenergic receptor subtype C2) (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR)
1_MDHQD 6_ PYSVQ 11_ ATAAI 16_ AAAIT 21_ FLILF 26_ TIFGN 31_ ALVIL 36_ AVLTS 41_ RSLRA 46_ PQNLF 51_ LVSLA 56_ AADIL 61_ VATLI 66_ IPFSL 71_ ANELL 76_ GYWYF 81_ RRTWC 86_ EVYLA 91_ LDVLF 96_ CTSSI 101_ VHLCA 106_ ISLDR 111_ YWAVS 116_ RALEY 121_ NSKRT 126_ PRRIK 131_ CIILT 136_ VWLIA 141_ AVISL 146_ PPLIY 151_ KGDQG 156_ PQPRG 161_ RPQCK 166_ LNQEA 171_ WYILA 176_ SSIGS 181_ FFAPC 186_ LIMIL 191_ VYLRI 196_ YLIAK 201_ RSNRR 206_ GPRAK 211_ GGPGQ 216_ GESKQ 221_ PRPDH 226_ GGALA 231_ SAKLP 236_ ALASV 241_ ASARE 246_ VNGHS 251_ KSTGE 256_ KEEGE 261_ TPEDT 266_ GTRAL 271_ PPSWA 276_ ALPNS 281_ GQGQK 286_ EGVCG 291_ ASPED 296_ EAEEE 301_ EEEEE 306_ EEEEC 311_ EPQAV 316_ PVSPA 321_ SACSP 326_ PLQQP 331_ QGSRV 336_ LATLR 341_ GQVLL 346_ GRGVG 351_ AIGGQ 356_ WWRRR 361_ AQLTR 366_ EKRFT 371_ FVLAV 376_ VIGVF 381_ VLCWF 386_ PFFFS 391_ YSLGA 396_ ICPKH 401_ CKVPH 406_ GLFQF 411_ FFWIG 416_ YCNSS 421_ LNPVI 426_ YTIFN 431_ QDFRR 436_ AFRRI 441_LCRPW
1: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol