Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24)
1_MAAAK 6_ AEMQL 11_ MSPLQ 16_ ISDPF 21_ GSFPH 26_ SPTMD 31_ NYPKL 36_ EEMML 41_ LSNGA 46_ PQFLG 51_ AAGAP 56_ EGSGS 61_ NSSSS 66_ SSGGG 71_ GGGGG 76_ GSNSS 81_ SSSST 86_ FNPQA 91_ DTGEQ 96_ PYEHL 101_ TAESF 106_ PDISL 111_ NNEKV 116_ LVETS 121_ YPSQT 126_ TRLPP 131_ ITYTG 136_ RFSLE 141_ PAPNS 146_ GNTLW 151_ PEPLF 156_ SLVSG 161_ LVSMT 166_ NPPAS 171_ SSSAP 176_ SPAAS 181_ SASAS 186_ QSPPL 191_ SCAVP 196_ SNDSS 201_ PIYSA 206_ APTFP 211_ TPNTD 216_ IFPEP 221_ QSQAF 226_ PGSAG 231_ TALQY 236_ PPPAY 241_ PAAKG 246_ GFQVP 251_ MIPDY 256_ LFPQQ 261_ QGDLG 266_ LGTPD 271_ QKPFQ 276_ GLESR 281_ TQQPS 286_ LTPLS 291_ TIKAF 296_ ATQSG 301_ SQDLK 306_ ALNTS 311_ YQSQL 316_ IKPSR 321_ MRKYP 326_ NRPSK 331_ TPPHE 336_ RPYAC 341_ PVESC 346_ DRRFS 351_ RSDEL 356_ TRHIR 361_ IHTGQ 366_ KPFQC 371_ RICMR 376_ NFSRS 381_ DHLTT 386_ HIRTH 391_ TGEKP 396_ FACDI 401_ CGRKF 406_ ARSDE 411_ RKRHT 416_ KIHLR 421_ QKDKK 426_ ADKSV 431_ VASSA 436_ TSSLS 441_ SYPSP 446_ VATSY 451_ PSPVT 456_ TSYPS 461_ PATTS 466_ YPSPV 471_ PTSFS 476_ SPGSS 481_ TYPSP 486_ VHSGF 491_ PSPSV 496_ ATTYS 501_ SVPPA 506_ FPAQV 511_ SSFPS 516_ SAVTN 521_ SFSAS 526_ TGLSD 531_ MTATF 536_SPRTI
1: Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity)