Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)
1_MDSWF 6_ ILVLL 11_ GSGLI 16_ CVSAN 21_ NATTV 26_ APSVG 31_ ITRLI 36_ NSSTA 41_ EPVKE 46_ EAKTS 51_ NPTSS 56_ LTSLS 61_ VAPTF 66_ SPNIT 71_ LGPTY 76_ LTTVN 81_ SSDSD 86_ NGTTR 91_ TASTN 96_ SIGIT 101_ ISPNG 106_ TWLPD 111_ NQFTD 116_ ARTEP 121_ WEGNS 126_ STAAT 131_ TPETF 136_ PPSGN 141_ SDSKD 146_ RRDET 151_ PIIAV 156_ MVALS 161_ SLLVI 166_ VFIII 171_ VLYML 176_ RFKKY 181_ KQAGS 186_ HSNSF 191_ RLSNG 196_ RTEDV 201_ EPQSV 206_ PLLAR 211_ SPSTN 216_ RKYPP 221_ LPVDK 226_ LEEEI 231_ NRRMA 236_ DDNKL 241_ FREEF 246_ NALPA 251_ CPIQA 256_ TCEAA 261_ SKEEN 266_ KEKNR 271_ YVNIL 276_ PYDHS 281_ RVHLT 286_ PVEGV 291_ PDSDY 296_ INASF 301_ INGYQ 306_ EKNKF 311_ IAAQG 316_ PKEET 321_ VNDFW 326_ RMIWE 331_ QNTAT 336_ IVMVT 341_ NLKER 346_ KECKC 351_ AQYWP 356_ DQGCW 361_ TYGNI 366_ RVSVE 371_ DVTVL 376_ VDYTV 381_ RKFCI 386_ QQVGD 391_ MTNRK 396_ PQRLI 401_ TQFHF 406_ TSWPD 411_ FGVPF 416_ TPIGM 421_ LKFLK 426_ KVKAC 431_ NPQYA 436_ GAIVV 441_ HCSAG 446_ VGRTG 451_ TFVVI 456_ DAMLD 461_ MMHTE 466_ RKVDV 471_ YGFVS 476_ RIRAQ 481_ RCQMV 486_ QTDMQ 491_ YVFIY 496_ QALLE 501_ HYLYG 506_ DTELE 511_ VTSLE 516_ THLQK 521_ IYNKI 526_ PGTSN 531_ NGLEE 536_ EFKKL 541_ TSIKI 546_ QNDKM 551_ RTGNL 556_ PANMK 561_ KNRVL 566_ QIIPY 571_ EFNRV 576_ IIPVK 581_ RGEEN 586_ TDYVN 591_ ASFID 596_ GYRQK 601_ DSYIA 606_ SQGPL 611_ LHTIE 616_ DFWRM 621_ IWEWK 626_ SCSIV 631_ MLTEL 636_ EERGQ 641_ EKCAQ 646_ YWPSD 651_ GLVSY 656_ GDITV 661_ ELKKE 666_ EECES 671_ YTVRD 676_ LLVTN 681_ TRENK 686_ SRQIR 691_ QFHFH 696_ GWPEV 701_ GIPSD 706_ GKGMI 711_ SIIAA 716_ VQKQQ 721_ QQSGN 726_ HPITV 731_ HCSAG 736_ AGRTG 741_ TFCAL 746_ STVLE 751_ RVKAE 756_ GILDV 761_ FQTVK 766_ SLRLQ 771_ RPHMV 776_ QTLEQ 781_ YEFCY 786_ KVVQE 791_ YIDAF 796_SDYAN
1: Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity)