Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1)
1_MWTVQ 6_ NRESL 11_ GLLSF 16_ PVMIT 21_ MVCCA 26_ HSTNE 31_ PSNMS 36_ YVKET 41_ VDRLL 46_ KGYDI 51_ RLRPD 56_ FGGPP 61_ VDVGM 66_ RIDVA 71_ SIDMV 76_ SEVNM 81_ DYTLT 86_ MYFQQ 91_ SWKDK 96_ RLSYS 101_ GIPLN 106_ LTLDN 111_ RVADQ 116_ LWVPD 121_ TYFLN 126_ DKKSF 131_ VHGVT 136_ VKNRM 141_ IRLHP 146_ DGTVL 151_ YGLRI 156_ TTTAA 161_ CMMDL 166_ RRYPL 171_ DEQNC 176_ TLEIE 181_ SYGYT 186_ TDDIE 191_ FYWNG 196_ GEGAV 201_ TGVNK 206_ IELPQ 211_ FSIVD 216_ YKMVS 221_ KKVEF 226_ TTGAY 231_ PRLSL 236_ SFRLK 241_ RNIGY 246_ FILQT 251_ YMPST 256_ LITIL 261_ SWVSF 266_ WINYD 271_ ASAAR 276_ VALGI 281_ TTVLT 286_ MTTIS 291_ THLRE 296_ TLPKI 301_ PYVKA 306_ IDIYL 311_ MGCFV 316_ FVFLA 321_ LLEYA 326_ FVNYI 331_ FFGKG 336_ PQKKG 341_ ASKQD 346_ QSANE 351_ KNKLE 356_ MNKVQ 361_ VDAHG 366_ NILLS 371_ TLEIR 376_ NETSG 381_ SEVLT 386_ SVSDP 391_ KATMY 396_ SYDSA 401_ SIQYR 406_ KPLSS 411_ REAYG 416_ RALDR 421_ HGVPS 426_ KGRIR 431_ RRASQ 436_ LKVKI 441_ PDLTD 446_ VNSID 451_ KWSRM 456_ FFPIT 461_ FSLFN 466_VVYWL
1: Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:16412217, PubMed:26950270). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain one or two GABA active binding sites located at the alpha and beta subunit interfaces, depending on subunit composition (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10449790, PubMed:16412217, PubMed:26950270). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:16412217, PubMed:26950270). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity)