Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2)
1_MSSPN 6_ IWSTG 11_ SSVYS 16_ TPVFS 21_ QKMTV 26_ WILLL 31_ LSLYP 36_ GFTSQ 41_ KSDDD 46_ YEDYA 51_ SNKTW 56_ VLTPK 61_ VPEGD 66_ VTVIL 71_ NNLLE 76_ GYDNK 81_ LRPDI 86_ GVKPT 91_ LIHTD 96_ MYVNS 101_ IGPVN 106_ AINME 111_ YTIDI 116_ FFAQT 121_ WYDRR 126_ LKFNS 131_ TIKVL 136_ RLNSN 141_ MVGKI 146_ WIPDT 151_ FFRNS 156_ KKADA 161_ HWITT 166_ PNRML 171_ RIWND 176_ GRVLY 181_ TLRLT 186_ IDAEC 191_ QLQLH 196_ NFPMD 201_ EHSCP 206_ LEFSS 211_ YGYPR 216_ EEIVY 221_ QWKRS 226_ SVEVG 231_ DTRSW 236_ RLYQF 241_ SFVGL 246_ RNTTE 251_ VVKTT 256_ SGDYV 261_ VMSVY 266_ FDLSR 271_ RMGYF 276_ TIQTY 281_ IPCTL 286_ IVVLS 291_ WVSFW 296_ INKDA 301_ VPART 306_ SLGIT 311_ TVLTM 316_ TTLST 321_ IARKS 326_ LPKVS 331_ YVTAM 336_ DLFVS 341_ VCFIF 346_ VFSAL 351_ VEYGT 356_ LHYFV 361_ SNRKP 366_ SKDKD 371_ KKKKN 376_ PAPTI 381_ DIRPR 386_ SATIQ 391_ MNNAT 396_ HLQER 401_ DEEYG 406_ YECLD 411_ GKDCA 416_ SFFCC 421_ FEDCR 426_ TGAWR 431_ HGRIH 436_ IRIAK 441_ MDSYA 446_ RIFFP 451_ TAFCL 456_ FNLVY 461_WVSYL
1: Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:16412217, PubMed:23909897, PubMed:2538761, PubMed:25489750, PubMed:27864268, PubMed:29950725, PubMed:30602789). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:29950725, PubMed:30602789). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:14993607, PubMed:16412217, PubMed:2538761, PubMed:27864268, PubMed:29950725, PubMed:30602789). Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:23909897, PubMed:25489750). Extrasynaptic gamma-2-containing receptors contribute to the tonic GABAergic inhibition (By similarity). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity)