Integrin beta-6
1_MGIEL 6_ LCLFF 11_ LFLGR 16_ NDHVQ 21_ GGCAL 26_ GGAET 31_ CEDCL 36_ LIGPQ 41_ CAWCA 46_ QENFT 51_ HPSGV 56_ GERCD 61_ TPANL 66_ LAKGC 71_ QLNFI 76_ ENPVS 81_ QVEIL 86_ KNKPL 91_ SVGRQ 96_ KNSSD 101_ IVQIA 106_ PQSLI 111_ LKLRP 116_ GGAQT 121_ LQVHV 126_ RQTED 131_ YPVDL 136_ YYLMD 141_ LSASM 146_ DDDLN 151_ TIKEL 156_ GSRLS 161_ KEMSK 166_ LTSNF 171_ RLGFG 176_ SFVEK 181_ PVSPF 186_ VKTTP 191_ EEIAN 196_ PCSSI 201_ PYFCL 206_ PTFGF 211_ KHILP 216_ LTNDA 221_ ERFNE 226_ IVKNQ 231_ KISAN 236_ IDTPE 241_ GGFDA 246_ IMQAA 251_ VCKEK 256_ IGWRN 261_ DSLHL 266_ LVFVS 271_ DADSH 276_ FGMDS 281_ KLAGI 286_ VIPND 291_ GLCHL 296_ DSKNE 301_ YSMST 306_ VLEYP 311_ TIGQL 316_ IDKLV 321_ QNNVL 326_ LIFAV 331_ TQEQV 336_ HLYEN 341_ YAKLI 346_ PGATV 351_ GLLQK 356_ DSGNI 361_ LQLII 366_ SAYEE 371_ LRSEV 376_ ELEVL 381_ GDTEG 386_ LNLSF 391_ TAICN 396_ NGTLF 401_ QHQKK 406_ CSHMK 411_ VGDTA 416_ SFSVT 421_ VNIPH 426_ CERRS 431_ RHIII 436_ KPVGL 441_ GDALE 446_ LLVSP 451_ ECNCD 456_ CQKEV 461_ EVNSS 466_ KCHHG 471_ NGSFQ 476_ CGVCA 481_ CHPGH 486_ MGPRC 491_ ECGED 496_ MLSTD 501_ SCKEA 506_ PDHPS 511_ CSGRG 516_ DCYCG 521_ QCICH 526_ LSPYG 531_ NIYGP 536_ YCQCD 541_ NFSCV 546_ RHKGL 551_ LCGGN 556_ GDCDC 561_ GECVC 566_ RSGWT 571_ GEYCN 576_ CTTST 581_ DSCVS 586_ EDGVL 591_ CSGRG 596_ DCVCG 601_ KCVCT 606_ NPGAS 611_ GPTCE 616_ RCPTC 621_ GDPCN 626_ SKRSC 631_ IECHL 636_ SAAGQ 641_ AREEC 646_ VDKCK 651_ LAGAT 656_ ISEEE 661_ DFSKD 666_ GSVSC 671_ SLQGE 676_ NECLI 681_ TFLIT 686_ TDNEG 691_ KTIIH 696_ SINEK 701_ DCPKP 706_ PNIPM 711_ IMLGV 716_ SLAIL 721_ LIGVV 726_ LLCIW 731_ KLLVS 736_ FHDRK 741_ EVAKF 746_ EAERS 751_ KAKWQ 756_ TGTNP 761_ LYRGS 766_ TSTFK 771_ NVTYK 776_ HREKQ 781_KVDLS
1: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17158881, PubMed:17545607). It recognizes the sequence R-G-D in its ligands (PubMed:17158881, PubMed:17545607). Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17158881, PubMed:17545607). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447)
2: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1
3: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260)