Negative elongation factor E (NELF-E) (RNA-binding protein RD)
1_MLVIP 6_ PGLSE 11_ EEEAL 16_ QKKFN 21_ KLKKK 26_ KKALL 31_ ALKKQ 36_ SSSST 41_ TSQGG 46_ VKRSL 51_ SEQPV 56_ MDTAT 61_ ATEQA 66_ KQLVK 71_ SGAIS 76_ AIKAE 81_ TKNSG 86_ FKRSR 91_ TLEGK 96_ LKDPE 101_ KGPVP 106_ TFQPF 111_ QRSIS 116_ ADDDL 121_ QESSR 126_ RPQRK 131_ SLYES 136_ FVSSS 141_ DRLRE 146_ LGPDG 151_ EEAEG 156_ PGAGD 161_ GPPRS 166_ FDWGY 171_ EERSG 176_ AHSSA 181_ SPPRS 186_ RSRDR 191_ SHERN 196_ RDRDR 201_ DRERD 206_ RDRDR 211_ DRDRE 216_ RDRDR 221_ DRDRD 226_ RDRER 231_ DRDRE 236_ RDRDR 241_ DREGP 246_ FRRSD 251_ SFPER 256_ RAPRK 261_ GNTLY 266_ VYGED 271_ MTPTL 276_ LRGAF 281_ SPFGN 286_ IIDLS 291_ MDPPR 296_ NCAFV 301_ TYEKM 306_ ESADQ 311_ AVAEL 316_ NGTQV 321_ ESVQL 326_ KVNIA 331_ RKQPM 336_ LDAAT 341_ GKSVW 346_ GSLAV 351_ QNSPK 356_ GCHRD 361_ KRTQI 366_ VYSDD 371_VYKEN
1: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401, PubMed:27256882). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062, PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27256882, PubMed:27282391)
2: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II