Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)
1_MSPKR 6_ IAKRR 11_ SPPAD 16_ AIPKS 21_ KKVKV 26_ SHRSH 31_ STEPG 36_ LVLTL 41_ GQGDV 46_ GQLGL 51_ GENVM 56_ ERKKP 61_ ALVSI 66_ PEDVV 71_ QAEAG 76_ GMHTV 81_ CLSKS 86_ GQVYS 91_ FGCND 96_ EGALG 101_ RDTSV 106_ EGSEM 111_ VPGKV 116_ ELQEK 121_ VVQVS 126_ AGDSH 131_ TAALT 136_ DDGRV 141_ FLWGS 146_ FRDNN 151_ GVIGL 156_ LEPMK 161_ KSMVP 166_ VQVQL 171_ DVPVV 176_ KVASG 181_ NDHLV 186_ MLTAD 191_ GDLYT 196_ LGCGE 201_ QGQLG 206_ RVPEL 211_ FANRG 216_ GRQGL 221_ ERLLV 226_ PKCVM 231_ LKSRG 236_ SRGHV 241_ RFQDA 246_ FCGAY 251_ FTFAI 256_ SHEGH 261_ VYGFG 266_ LSNYH 271_ QLGTP 276_ GTESC 281_ FIPQN 286_ LTSFK 291_ NSTKS 296_ WVGFS 301_ GGQHH 306_ TVCMD 311_ SEGKA 316_ YSLGR 321_ AEYGR 326_ LGLGE 331_ GAEEK 336_ SIPTL 341_ ISRLP 346_ AVSSV 351_ ACGAS 356_ VGYAV 361_ TKDGR 366_ VFAWG 371_ MGTNY 376_ QLGTG 381_ QDEDA 386_ WSPVE 391_ MMGKQ 396_ LENRV 401_ VLSVS 406_ SGGQH 411_ TVLLV 416_KDKEQ
1: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580)