Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36)
1_MEDSH 6_ KSTTS 11_ ETAPQ 16_ PGSAV 21_ QGAHI 26_ SHIAQ 31_ QVSSL 36_ SESEE 41_ SQDSS 46_ DSIGS 51_ SQKAH 56_ GILAR 61_ RPSYR 66_ KILKD 71_ LSSED 76_ TRGRK 81_ GDGEN 86_ SGVSA 91_ AVTSM 96_ SVPTP 101_ IYQTS 106_ SGQYI 111_ AIAPN 116_ GALQL 121_ ASPGT 126_ DGVQG 131_ LQTLT 136_ MTNSG 141_ STQQG 146_ TTILQ 151_ YAQTS 156_ DGQQI 161_ LVPSN 166_ QVVVQ 171_ TASGD 176_ MQTYQ 181_ IRTTP 186_ SATSL 191_ PQTVV 196_ MTSPV 201_ TLTSQ 206_ TTKTD 211_ DPQLK 216_ REIRL 221_ MKNRE 226_ AAREC 231_ RRKKK 236_ EYVKC 241_ LENRV 246_ AVLEN 251_ QNKTL 256_ IEELK 261_ TLKDL 266_YSNKS
1: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation