Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)
1_MMLQH 6_ PGQVS 11_ ASEVS 16_ ASAIV 21_ PCLSP 26_ PGSLV 31_ FEDFA 36_ NLTPF 41_ VKEEL 46_ RFAIQ 51_ NKHLC 56_ HRMSS 61_ ALESV 66_ TVSDR 71_ PLGVS 76_ ITKAE 81_ VAPEE 86_ DERKK 91_ RRRER 96_ NKIAA 101_ AKCRN 106_ KKKEK 111_ TECLQ 116_ KESEK 121_ LESVN 126_ AELKA 131_ QIEEL 136_ KNEKQ 141_ HLIYM 146_ LNLHR 151_ PTCIV 156_ RAQNG 161_ RTPED 166_ ERNLF 171_ IQQIK 176_EGTLQ
1: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter
2: Activates transcription presumably by sequestering inhibitory cofactors away from the promoters
3: Stress-induced isoform, counteracts the transcriptional repression of isoform 1