Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha]
1_MGEPA 6_ GVAGT 11_ MESPF 16_ SPGLF 21_ HRLDE 26_ DWDSA 31_ LFAEL 36_ GYFTD 41_ TDELQ 46_ LEAAN 51_ ETYEN 56_ NFDNL 61_ DFDLD 66_ LMPWE 71_ SDIWD 76_ INNQI 81_ CTVKD 86_ IKAEP 91_ QPLSP 96_ ASSSY 101_ SVSSP 106_ RSVDS 111_ YSSTQ 116_ HVPEE 121_ LDLSS 126_ SSQMS 131_ PLSLY 136_ GENSN 141_ SLSSA 146_ EPLKE 151_ DKPVT 156_ GPRNK 161_ TENGL 166_ TPKKK 171_ IQVNS 176_ KPSIQ 181_ PKPLL 186_ LPAAP 191_ KTQTN 196_ SSVPA 201_ KTIII 206_ QTVPT 211_ LMPLA 216_ KQQPI 221_ ISLQP 226_ APTKG 231_ QTVLL 236_ SQPTV 241_ VQLQA 246_ PGVLP 251_ SAQPV 256_ LAVAG 261_ GVTQL 266_ PNHVV 271_ NVVPA 276_ PSANS 281_ PVNGK 286_ LSVTK 291_ PVLQS 296_ TMRNV 301_ GSDIA 306_ VLRRQ 311_ QRMIK 316_ NRESA 321_ CQSRK 326_ KKKEY 331_ MLGLE 336_ ARLKA 341_ ALSEN 346_ EQLKK 351_ ENGTL 356_ KRQLD 361_ EVVSE 366_ NQRLK 371_ VPSPK 376_ RRVVC 381_ VMIVL 386_ AFIIL 391_ NYGPM 396_ SMLEQ 401_ DSRRM 406_ NPSVS 411_ PANQR 416_ RHLLG 421_ FSAKE 426_ AQDTS 431_ DGIIQ 436_ KNSYR 441_ YDHSV 446_ SNDKA 451_ LMVLT 456_ EEPLL 461_ YIPPP 466_ PCQPL 471_ INTTE 476_ SLRLN 481_ HELRG 486_ WVHRH 491_ EVERT 496_ KSRRM 501_ TNNQQ 506_ KTRIL 511_ QGALE 516_ QGSNS 521_ QLMAV 526_ QYTET 531_ TSSIS 536_ RNSGS 541_ ELQVY 546_ YASPR 551_ SYQDF 556_ FEAIR 561_ RRGDT 566_ FYVVS 571_ FRRDH 576_ LLLPA 581_ TTHNK 586_ TTRPK 591_ MSIVL 596_ PAINI 601_ NENVI 606_ NGQDY 611_ EVMMQ 616_ IDCQV 621_ MDTRI 626_ LHIKS 631_ SSVPP 636_ YLRDQ 641_ QRNQT 646_ NTFFG 651_ SPPAA 656_ TEATH 661_VVSTI
1: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed:10564271, PubMed:11158310, PubMed:11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:10564271, PubMed:11158310, PubMed:11779464)
2: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR (PubMed:10564271, PubMed:11158310, PubMed:11163209, PubMed:11779464). Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') (PubMed:10564271, PubMed:11158310, PubMed:11779464). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (PubMed:10564271, PubMed:11158310, PubMed:11779464). May play a role in foveal development and cone function in the retina (PubMed:26029869)