DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)
1_MPEIR 6_ LRHVV 11_ SCSSQ 16_ DSTHC 21_ AENLL 26_ KADTY 31_ RKWRA 36_ AKAGE 41_ KTISV 46_ VLQLE 51_ KEEQI 56_ HSVDI 61_ GNDGS 66_ AFVEV 71_ LVGSS 76_ AGGAG 81_ EQDYE 86_ VLLVT 91_ SSFMS 96_ PSESR 101_ SGSNP 106_ NRVRM 111_ FGPDK 116_ LVRAA 121_ AEKRW 126_ DRVKI 131_ VCSQP 136_ YSKDS 141_ PFGLS 146_ FVRFH 151_ SPPDK 156_ DEAEA 161_ PSQKV 166_ TVTKL 171_ GQFRV 176_ KEEDE 181_ SANSL 186_ RPGAL 191_ FFSRI 196_ NKTSP 201_ VTASD 206_ PAGPS 211_ YAAAT 216_ LQASS 221_ AASSA 226_ SPVSR 231_ AIGST 236_ SKPQE 241_ SPKGK 246_ RKLDL 251_ NQEEK 256_ KTPSK 261_ PPAQL 266_ SPSVP 271_ KRPKL 276_ PAPTR 281_ TPATA 286_ PVPAR 291_ AQGAV 296_ TGKPR 301_ GEGTE 306_ PRRPR 311_ AGPEE 316_ LGKIL 321_ QGVVV 326_ VLSGF 331_ QNPFR 336_ SELRD 341_ KALEL 346_ GAKYR 351_ PDWTR 356_ DSTHL 361_ ICAFA 366_ NTPKY 371_ SQVLG 376_ LGGRI 381_ VRKEW 386_ VLDCH 391_ RMRRR 396_ LPSQR 401_ YLMAG 406_ PGSSS 411_ EEDEA 416_ SHSGG 421_ SGDEA 426_ PKLPQ 431_ KQPQT 436_ KTKPT 441_ QAAGP 446_ SSPQK 451_ PPTPE 456_ ETKAA 461_ SPVLQ 466_ EDIDI 471_ EGVQS 476_ EGQDN 481_ GAEDS 486_ GDTED 491_ ELRRV 496_ AEQKE 501_ HRLPP 506_ GQEEN 511_ GEDPY 516_ AGSTD 521_ ENTDS 526_ EEHQE 531_ PPDLP 536_ VPELP 541_ DFFQG 546_ KHFFL 551_ YGEFP 556_ GDERR 561_ KLIRY 566_ VTAFN 571_ GELED 576_ YMSDR 581_ VQFVI 586_ TAQEW 591_ DPSFE 596_ EALMD 601_ NPSLA 606_ FVRPR 611_ WIYSC 616_ NEKQK 621_ LLPHQ 626_LYGVV
1: Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483)