Tetraspanin-8 (Tspan-8) (Transmembrane 4 superfamily member 3) (Tumor-associated antigen CO-029)
1_MAGVS 6_ ACIKY 11_ SMFTF 16_ NFLFW 21_ LCGIL 26_ ILALA 31_ IWVRV 36_ SNDSQ 41_ AIFGS 46_ EDVGS 51_ SSYVA 56_ VDILI 61_ AVGAI 66_ IMILG 71_ FLGCC 76_ GAIKE 81_ SRCML 86_ LLFFI 91_ GLLLI 96_ LLLQV 101_ ATGIL 106_ GAVFK 111_ SKSDR 116_ IVNET 121_ LYENT 126_ KLLSA 131_ TGESE 136_ KQFQE 141_ AIIVF 146_ QEEFK 151_ CCGLV 156_ NGAAD 161_ WGNNF 166_ QHYPE 171_ LCACL 176_ DKQRP 181_ CQSYN 186_ GKQVY 191_ KETCI 196_ SFIKD 201_ FLAKN 206_ LIIVI 211_ GISFG 216_ LAVIE 221_ ILGLV 226_ FSMVL 231_YCQIG
1: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed:27180357, PubMed:36078095). Participates thereby in diverse biological functions such as cell signal transduction, migration and protein trafficking (PubMed:25761241). Promotes ADAM17-mediated TNF-alpha processing through recruitment of ADAM17 to tetraspanin-enriched micro-domains (TEMs) (PubMed:36078095). Forms a complex with RICTOR and integrin alpha3/ITGA3 to mediate mTORC2 activation and AKT1 phosphorylation leading to cell migration (PubMed:25761241). Reduces apoptosis and autophagy induced by high glucose levels through forming a complex with mTOR and RICTOR (PubMed:35904232). Contributes to the maintenance of intestinal epithelial barrier and plays a role in the regulation of intestine inflammation by switching interferon gamma receptor 1/IFNGR1 from clathrin-dependent to lipid raft-dependent endocytosis route to limit STAT1 activation magnitude and duration (PubMed:37204469). Acts as a modulator of the endothelin axis by associating with endothelin converting enzyme ECE1 and regulating its activity of conversion of the endothelin-1 precursor to endothelin (PubMed:37835445)