Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (CYPXIB2) (Corticosterone 18-monooxygenase, CYP11B2) (EC 1.14.15.5) (Cytochrome P-450Aldo) (Cytochrome P-450C18) (Steroid 11-beta-hydroxylase, CYP11B2) (EC 1.14.15.4) (Steroid 18-hydroxylase)
1_MALRA 6_ KAEVC 11_ VAAPW 16_ LSLQR 21_ ARALG 26_ TRAAR 31_ APRTV 36_ LPFEA 41_ MPQHP 46_ GNRWL 51_ RLLQI 56_ WREQG 61_ YEHLH 66_ LEMHQ 71_ TFQEL 76_ GPIFR 81_ YNLGG 86_ PRMVC 91_ VMLPE 96_ DVEKL 101_ QQVDS 106_ LHPCR 111_ MILEP 116_ WVAYR 121_ QHRGH 126_ KCGVF 131_ LLNGP 136_ EWRFN 141_ RLRLN 146_ PDVLS 151_ PKAVQ 156_ RFLPM 161_ VDAVA 166_ RDFSQ 171_ ALKKK 176_ VLQNA 181_ RGSLT 186_ LDVQP 191_ SIFHY 196_ TIEAS 201_ NLALF 206_ GERLG 211_ LVGHS 216_ PSSAS 221_ LNFLH 226_ ALEVM 231_ FKSTV 236_ QLMFM 241_ PRSLS 246_ RWISP 251_ KVWKE 256_ HFEAW 261_ DCIFQ 266_ YGDNC 271_ IQKIY 276_ QELAF 281_ NRPQH 286_ YTGIV 291_ AELLL 296_ KAELS 301_ LEAIK 306_ ANSME 311_ LTAGS 316_ VDTTA 321_ FPLLM 326_ TLFEL 331_ ARNPD 336_ VQQIL 341_ RQESL 346_ AAAAS 351_ ISEHP 356_ QKATT 361_ ELPLL 366_ RAALK 371_ ETLRL 376_ YPVGL 381_ FLERV 386_ VSSDL 391_ VLQNY 396_ HIPAG 401_ TLVQV 406_ FLYSL 411_ GRNAA 416_ LFPRP 421_ ERYNP 426_ QRWLD 431_ IRGSG 436_ RNFHH 441_ VPFGF 446_ GMRQC 451_ LGRRL 456_ AEAEM 461_ LLLLH 466_ HVLKH 471_ FLVET 476_ LTQED 481_ IKMVY 486_ SFILR 491_ PGTSP 496_LLTFR
1: A cytochrome P450 monooxygenase that catalyzes the biosynthesis of aldosterone, the main mineralocorticoid in the human body responsible for salt and water homeostasis, thus involved in blood pressure regulation, arterial hypertension, and the development of heart failure (PubMed:11856349, PubMed:12530636, PubMed:1518866, PubMed:15356073, PubMed:1594605, PubMed:1775135, PubMed:22446688, PubMed:23322723, PubMed:9814482, PubMed:9814506). Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone (21-hydroxyprogesterone), namely 11-beta hydroxylation, followed by two successive oxidations at C18 yielding 18-hydroxy and then 18-oxo intermediates (that would not leave the enzyme active site during the consecutive hydroxylation reactions), ending with the formation of aldosterone (PubMed:11856349, PubMed:12530636, PubMed:1518866, PubMed:1594605, PubMed:1775135, PubMed:22446688, PubMed:23322723, PubMed:9814506). Can also produce 18-hydroxycortisol and 18-oxocortisol, derived from successive oxidations of cortisol at C18, normally found at very low levels, but significantly increased in primary aldosteronism, the most common form of secondary hypertension (PubMed:15356073, PubMed:9814482). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:11856349, PubMed:1594605, PubMed:23322723, PubMed:9814506). Could also be involved in the androgen metabolic pathway (Probable)