1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
1_MAGAA 6_ SPCAN 11_ GCGPG 16_ APSDA 21_ EVLHL 26_ CRSLE 31_ VGTVM 36_ TLFYS 41_ KKSQR 46_ PERKT 51_ FQVKL 56_ ETRQI 61_ TWSRG 66_ ADKIE 71_ GAIDI 76_ REIKE 81_ IRPGK 86_ TSRDF 91_ DRYQE 96_ DPAFR 101_ PDQSH 106_ CFVIL 111_ YGMEF 116_ RLKTL 121_ SLQAT 126_ SEDEV 131_ NMWIK 136_ GLTWL 141_ MEDTL 146_ QAPTP 151_ LQIER 156_ WLRKQ 161_ FYSVD 166_ RNRED 171_ RISAK 176_ DLKNM 181_ LSQVN 186_ YRVPN 191_ MRFLR 196_ ERLTD 201_ LEQRS 206_ GDITY 211_ GQFAQ 216_ LYRSL 221_ MYSAQ 226_ KTMDL 231_ PFLEA 236_ STLRA 241_ GERPE 246_ LCRVS 251_ LPEFQ 256_ QFLLD 261_ YQGEL 266_ WAVDR 271_ LQVQE 276_ FMLSF 281_ LRDPL 286_ REIEE 291_ PYFFL 296_ DEFVT 301_ FLFSK 306_ ENSVW 311_ NSQLD 316_ AVCPD 321_ TMNNP 326_ LSHYW 331_ ISSSH 336_ NTYLT 341_ GDQFS 346_ SESSL 351_ EAYAR 356_ CLRMG 361_ CRCIE 366_ LDCWD 371_ GPDGM 376_ PVIYH 381_ GHTLT 386_ TKIKF 391_ SDVLH 396_ TIKEH 401_ AFVAS 406_ EYPVI 411_ LSIED 416_ HCSIA 421_ QQRNM 426_ AQYFK 431_ KVLGD 436_ TLLTK 441_ PVEIS 446_ ADGLP 451_ SPNQL 456_ KRKIL 461_ IKHKK 466_ LAEGS 471_ AYEEV 476_ PTSMM 481_ YSEND 486_ ISNSI 491_ KNGIL 496_ YLEDP 501_ VNHEW 506_ YPHYF 511_ VLTSS 516_ KIYYS 521_ EETSS 526_ DQGNE 531_ DEEEP 536_ KEVSS 541_ STELH 546_ SNEKW 551_ FHGKL 556_ GAGRD 561_ GRHIA 566_ ERLLT 571_ EYCIE 576_ TGAPD 581_ GSFLV 586_ RESET 591_ FVGDY 596_ TLSFW 601_ RNGKV 606_ QHCRI 611_ HSRQD 616_ AGTPK 621_ FFLTD 626_ NLVFD 631_ SLYDL 636_ ITHYQ 641_ QVPLR 646_ CNEFE 651_ MRLSE 656_ PVPQT 661_ NAHES 666_ KEWYH 671_ ASLTR 676_ AQAEH 681_ MLMRV 686_ PRDGA 691_ FLVRK 696_ RNEPN 701_ SYAIS 706_ FRAEG 711_ KIKHC 716_ RVQQE 721_ GQTVM 726_ LGNSE 731_ FDSLV 736_ DLISY 741_ YEKHP 746_ LYRKM 751_ KLRYP 756_ INEEA 761_ LEKIG 766_ TAEPD 771_ YGALY 776_ EGRNP 781_ GFYVE 786_ ANPMP 791_ TFKCA 796_ VKALF 801_ DYKAQ 806_ REDEL 811_ TFIKS 816_ AIIQN 821_ VEKQE 826_ GGWWR 831_ GDYGG 836_ KKQLW 841_ FPSNY 846_ VEEMV 851_ NPVAL 856_ EPERE 861_ HLDEN 866_ SPLGD 871_ LLRGV 876_ LDVPA 881_ CQIAI 886_ RPEGK 891_ NNRLF 896_ VFSIS 901_ MASVA 906_ HWSLD 911_ VAADS 916_ QEELQ 921_ DWVKK 926_ IREVA 931_ QTADA 936_ RLTEG 941_ KIMER 946_ RKKIA 951_ LELSE 956_ LVVYC 961_ RPVPF 966_ DEEKI 971_ GTERA 976_ CYRDM 981_ SSFPE 986_ TKAEK 991_ YVNKA 996_ KGKKF 1001_ LQYNR 1006_ LQLSR 1011_ IYPKG 1016_ QRLDS 1021_ SNYDP 1026_ LPMWI 1031_ CGSQL 1036_ VALNF 1041_ QTPDK 1046_ PMQMN 1051_ QALFM 1056_ TGRHC 1061_ GYVLQ 1066_ PSTMR 1071_ DEAFD 1076_ PFDKS 1081_ SLRGL 1086_ EPCAI 1091_ SIEVL 1096_ GARHL 1101_ PKNGR 1106_ GIVCP 1111_ FVEIE 1116_ VAGAE 1121_ YDSTK 1126_ QKTEF 1131_ VVDNG 1136_ LNPVW 1141_ PAKPF 1146_ HFQIS 1151_ NPEFA 1156_ FLRFV 1161_ VYEED 1166_ MFSDQ 1171_ NFLAQ 1176_ ATFPV 1181_ KGLKT 1186_ GYRAV 1191_ PLKNN 1196_ YSEDL 1201_ ELASL 1206_ LIKID 1211_ IFPAK 1216_ ENGDL 1221_ SPFSG 1226_ TSLRE 1231_ RGSDA 1236_ SGQLF 1241_ HGRAR 1246_ EGSFE 1251_ SRYQQ 1256_ PFEDF 1261_ RISQE 1266_ HLADH 1271_ FDSRE 1276_ RRAPR 1281_RTRVN
1: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity)