UDP-glucuronosyltransferase 1-6 (UDPGT 1-6) (UGT1*6) (UGT1-06) (UGT1.6) (EC 2.4.1.17) (Phenol-metabolizing UDP-glucuronosyltransferase) (UDP-glucuronosyltransferase 1-F) (UGT-1F) (UGT1F) (UDP-glucuronosyltransferase 1A6)
1_MACLL 6_ RSFQR 11_ ISAGV 16_ FFLAL 21_ WGMVV 26_ GDKLL 31_ VVPQD 36_ GSHWL 41_ SMKDI 46_ VEVLS 51_ DRGHE 56_ IVVVV 61_ PEVNL 66_ LLKES 71_ KYYTR 76_ KIYPV 81_ PYDQE 86_ ELKNR 91_ YQSFG 96_ NNHFA 101_ ERSFL 106_ TAPQT 111_ EYRNN 116_ MIVIG 121_ LYFIN 126_ CQSLL 131_ QDRDT 136_ LNFFK 141_ ESKFD 146_ ALFTD 151_ PALPC 156_ GVILA 161_ EYLGL 166_ PSVYL 171_ FRGFP 176_ CSLEH 181_ TFSRS 186_ PDPVS 191_ YIPRC 196_ YTKFS 201_ DHMTF 206_ SQRVA 211_ NFLVN 216_ LLEPY 221_ LFYCL 226_ FSKYE 231_ ELASA 236_ VLKRD 241_ VDIIT 246_ LYQKV 251_ SVWLL 256_ RYDFV 261_ LEYPR 266_ PVMPN 271_ MVFIG 276_ GINCK 281_ KRKDL 286_ SQEFE 291_ AYINA 296_ SGEHG 301_ IVVFS 306_ LGSMV 311_ SEIPE 316_ KKAMA 321_ IADAL 326_ GKIPQ 331_ TVLWR 336_ YTGTR 341_ PSNLA 346_ NNTIL 351_ VKWLP 356_ QNDLL 361_ GHPMT 366_ RAFIT 371_ HAGSH 376_ GVYES 381_ ICNGV 386_ PMVMM 391_ PLFGD 396_ QMDNA 401_ KRMET 406_ KGAGV 411_ TLNVL 416_ EMTSE 421_ DLENA 426_ LKAVI 431_ NDKSY 436_ KENIM 441_ RLSSL 446_ HKDRP 451_ VEPLD 456_ LAVFW 461_ VEFVM 466_ RHKGA 471_ PHLRP 476_ AAHDL 481_ TWYQY 486_ HSLDV 491_ IGFLL 496_ AVVLT 501_ VAFIT 506_ FKCCA 511_ YGYRK 516_ CLGKK 521_ GRVKK 526_AHKSK
1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to facilitate their inactivation and excretion from the body (PubMed:15231852, PubMed:21422672). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15231852, PubMed:21422672). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE and 20-HETE (PubMed:15231852). Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate (By similarity). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (PubMed:21422672)
2: Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1