Gene name: EPOR

Uniprot entry:

P19235

Protein names:

Erythropoietin receptor (EPO-R)

Protein sequence:

1_MDHLG 6_ ASLWP 11_ QVGSL 16_ CLLLA 21_ GAAWA 26_ PPPNL 31_ PDPKF 36_ ESKAA 41_ LLAAR 46_ GPEEL 51_ LCFTE 56_ RLEDL 61_ VCFWE 66_ EAASA 71_ GVGPG 76_ NYSFS 81_ YQLED 86_ EPWKL 91_ CRLHQ 96_ APTAR 101_ GAVRF 106_ WCSLP 111_ TADTS 116_ SFVPL 121_ ELRVT 126_ AASGA 131_ PRYHR 136_ VIHIN 141_ EVVLL 146_ DAPVG 151_ LVARL 156_ ADESG 161_ HVVLR 166_ WLPPP 171_ ETPMT 176_ SHIRY 181_ EVDVS 186_ AGNGA 191_ GSVQR 196_ VEILE 201_ GRTEC 206_ VLSNL 211_ RGRTR 216_ YTFAV 221_ RARMA 226_ EPSFG 231_ GFWSA 236_ WSEPV 241_ SLLTP 246_ SDLDP 251_ LILTL 256_ SLILV 261_ VILVL 266_ LTVLA 271_ LLSHR 276_ RALKQ 281_ KIWPG 286_ IPSPE 291_ SEFEG 296_ LFTTH 301_ KGNFQ 306_ LWLYQ 311_ NDGCL 316_ WWSPC 321_ TPFTE 326_ DPPAS 331_ LEVLS 336_ ERCWG 341_ TMQAV 346_ EPGTD 351_ DEGPL 356_ LEPVG 361_ SEHAQ 366_ DTYLV 371_ LDKWL 376_ LPRNP 381_ PSEDL 386_ PGPGG 391_ SVDIV 396_ AMDEG 401_ SEASS 406_ CSSAL 411_ ASKPS 416_ PEGAS 421_ AASFE 426_ YTILD 431_ PSSQL 436_ LRPWT 441_ LCPEL 446_ PPTPP 451_ HLKYL 456_ YLVVS 461_ DSGIS 466_ TDYSS 471_ GDSQG 476_ AQGGL 481_ SDGPY 486_ SNPYE 491_ NSLIP 496_ AAEPL 501_PPSYV

Protein annotations

Protein functions:

1: Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation (PubMed:10388848, PubMed:2163695, PubMed:2163696, PubMed:8662939, PubMed:9774108). Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (By similarity). In some cell types, can also activate STAT1 and STAT3 (PubMed:11756159). May also activate the LYN tyrosine kinase (By similarity)

2: Acts as a dominant-negative receptor of EPOR-mediated signaling