Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106)
1_MPGKM 6_ VVILG 11_ ASNIL 16_ WIMFA 21_ ASQAF 26_ KIETT 31_ PESRY 36_ LAQIG 41_ DSVSL 46_ TCSTT 51_ GCESP 56_ FFSWR 61_ TQIDS 66_ PLNGK 71_ VTNEG 76_ TTSTL 81_ TMNPV 86_ SFGNE 91_ HSYLC 96_ TATCE 101_ SRKLE 106_ KGIQV 111_ EIYSF 116_ PKDPE 121_ IHLSG 126_ PLEAG 131_ KPITV 136_ KCSVA 141_ DVYPF 146_ DRLEI 151_ DLLKG 156_ DHLMK 161_ SQEFL 166_ EDADR 171_ KSLET 176_ KSLEV 181_ TFTPV 186_ IEDIG 191_ KVLVC 196_ RAKLH 201_ IDEMD 206_ SVPTV 211_ RQAVK 216_ ELQVY 221_ ISPKN 226_ TVISV 231_ NPSTK 236_ LQEGG 241_ SVTMT 246_ CSSEG 251_ LPAPE 256_ IFWSK 261_ KLDNG 266_ NLQHL 271_ SGNAT 276_ LTLIA 281_ MRMED 286_ SGIYV 291_ CEGVN 296_ LIGKN 301_ RKEVE 306_ LIVQE 311_ KPFTV 316_ EISPG 321_ PRIAA 326_ QIGDS 331_ VMLTC 336_ SVMGC 341_ ESPSF 346_ SWRTQ 351_ IDSPL 356_ SGKVR 361_ SEGTN 366_ STLTL 371_ SPVSF 376_ ENEHS 381_ YLCTV 386_ TCGHK 391_ KLEKG 396_ IQVEL 401_ YSFPR 406_ DPEIE 411_ MSGGL 416_ VNGSS 421_ VTVSC 426_ KVPSV 431_ YPLDR 436_ LEIEL 441_ LKGET 446_ ILENI 451_ EFLED 456_ TDMKS 461_ LENKS 466_ LEMTF 471_ IPTIE 476_ DTGKA 481_ LVCQA 486_ KLHID 491_ DMEFE 496_ PKQRQ 501_ STQTL 506_ YVNVA 511_ PRDTT 516_ VLVSP 521_ SSILE 526_ EGSSV 531_ NMTCL 536_ SQGFP 541_ APKIL 546_ WSRQL 551_ PNGEL 556_ QPLSE 561_ NATLT 566_ LISTK 571_ MEDSG 576_ VYLCE 581_ GINQA 586_ GRSRK 591_ EVELI 596_ IQVTP 601_ KDIKL 606_ TAFPS 611_ ESVKE 616_ GDTVI 621_ ISCTC 626_ GNVPE 631_ TWIIL 636_ KKKAE 641_ TGDTV 646_ LKSID 651_ GAYTI 656_ RKAQL 661_ KDAGV 666_ YECES 671_ KNKVG 676_ SQLRS 681_ LTLDV 686_ QGREN 691_ NKDYF 696_ SPELL 701_ VLYFA 706_ SSLII 711_ PAIGM 716_ IIYFA 721_ RKANM 726_ KGSYS 731_LVEAQ
1: Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins (PubMed:10209034). During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration (PubMed:22970700). Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation (PubMed:35210567)