Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A)
1_MIAAQ 6_ LLAYY 11_ FTELK 16_ DDQVK 21_ KIDKY 26_ LYAMR 31_ LSDET 36_ LIDIM 41_ TRFRK 46_ EMKNG 51_ LSRDF 56_ NPTAT 61_ VKMLP 66_ TFVRS 71_ IPDGS 76_ EKGDF 81_ IALDL 86_ GGSSF 91_ RILRV 96_ QVNHE 101_ KNQNV 106_ HMESE 111_ VYDTP 116_ ENIVH 121_ GSGSQ 126_ LFDHV 131_ AECLG 136_ DFMEK 141_ RKIKD 146_ KKLPV 151_ GFTFS 156_ FPCQQ 161_ SKIDE 166_ AILIT 171_ WTKRF 176_ KASGV 181_ EGADV 186_ VKLLN 191_ KAIKK 196_ RGDYD 201_ ANIVA 206_ VVNDT 211_ VGTMM 216_ TCGYD 221_ DQHCE 226_ VGLII 231_ GTGTN 236_ ACYME 241_ ELRHI 246_ DLVEG 251_ DEGRM 256_ CINTE 261_ WGAFG 266_ DDGSL 271_ EDIRT 276_ EFDRE 281_ IDRGS 286_ LNPGK 291_ QLFEK 296_ MVSGM 301_ YLGEL 306_ VRLIL 311_ VKMAK 316_ EGLLF 321_ EGRIT 326_ PELLT 331_ RGKFN 336_ TSDVS 341_ AIEKN 346_ KEGLH 351_ NAKEI 356_ LTRLG 361_ VEPSD 366_ DDCVS 371_ VQHVC 376_ TIVSF 381_ RSANL 386_ VAATL 391_ GAILN 396_ RLRDN 401_ KGTPR 406_ LRTTV 411_ GVDGS 416_ LYKTH 421_ PQYSR 426_ RFHKT 431_ LRRLV 436_ PDSDV 441_ RFLLS 446_ ESGSG 451_ KGAAM 456_ VTAVA 461_ YRLAE 466_ QHRQI 471_ EETLA 476_ HFHLT 481_ KDMLL 486_ EVKKR 491_ MRAEM 496_ ELGLR 501_ KQTHN 506_ NAVVK 511_ MLPSF 516_ VRRTP 521_ DGTEN 526_ GDFLA 531_ LDLGG 536_ TNFRV 541_ LLVKI 546_ RSGKK 551_ RTVEM 556_ HNKIY 561_ AIPIE 566_ IMQGT 571_ GEELF 576_ DHIVS 581_ CISDF 586_ LDYMG 591_ IKGPR 596_ MPLGF 601_ TFSFP 606_ CQQTS 611_ LDAGI 616_ LITWT 621_ KGFKA 626_ TDCVG 631_ HDVVT 636_ LLRDA 641_ IKRRE 646_ EFDLD 651_ VVAVV 656_ NDTVG 661_ TMMTC 666_ AYEEP 671_ TCEVG 676_ LIVGT 681_ GSNAC 686_ YMEEM 691_ KNVEM 696_ VEGDQ 701_ GQMCI 706_ NMEWG 711_ AFGDN 716_ GCLDD 721_ IRTHY 726_ DRLVD 731_ EYSLN 736_ AGKQR 741_ YEKMI 746_ SGMYL 751_ GEIVR 756_ NILID 761_ FTKKG 766_ FLFRG 771_ QISET 776_ LKTRG 781_ IFETK 786_ FLSQI 791_ ESDRL 796_ ALLQV 801_ RAILQ 806_ QLGLN 811_ STCDD 816_ SILVK 821_ TVCGV 826_ VSRRA 831_ AQLCG 836_ AGMAA 841_ VVDKI 846_ RENRG 851_ LDRLN 856_ VTVGV 861_ DGTLY 866_ KLHPH 871_ FSRIM 876_ HQTVK 881_ ELSPK 886_ CNVSF 891_ LLSED 896_ GSGKG 901_ AALIT 906_ AVGVR 911_LRTEA
1: Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331)